POU2AF1 and MSX2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		POU2AF1	MSX2
Gene Name		POU class 2 associating factor 1	msh homeobox 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Transcription Factor Complex
	Molecular Function	DNA Binding Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Cofactor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Humoral Immune Response	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Chondrocyte Development Osteoblast Development Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endochondral Bone Growth Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of BMP Signaling Pathway Negative Regulation Of CREB Transcription Factor Activity Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Embryonic Nail Plate Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Catagen Bone Trabecula Formation Cranial Suture Morphogenesis Frontal Suture Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis BMP Signaling Pathway Involved In Heart Development Enamel Mineralization Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Activation Of Meiosis Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Primary biliary cirrhosis ( 23000144)
Protein-Protein Interactions		16 interactors: GATA2 GTF2H1 GTF2I MSX2 NAB1 PAX8 POU2F1 POU2F2 RHOXF2 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK	21 interactors: ATXN1 CEBPA DLX2 DLX5 GTF2F1 GTF2F2 MAGED1 MSX1 NR3C1 PIAS2 POLR3D POU2AF1 PPARG RUNX2 SPEN TLE1 TLE2 XRCC5 XRCC6 ZBTB17 ZDHHC2
Entrez ID		5450	4488
HPRD ID		03126	00421
Ensembl ID		ENSG00000110777	ENSG00000120149
Uniprot IDs		Q16633	P35548
PDB IDs		1CQT
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Organ Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Anatomical Structure Morphogenesis RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Differentiation Ammonium Transport Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Quaternary Ammonium Group Transport Negative Regulation Of RNA Biosynthetic Process System Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Monoamine Transport Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Stimulus Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Drug Transmembrane Transport Signal Transduction Involved In Regulation Of Gene Expression Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Secretion By Cell Organ Development Positive Regulation Of BMP Signaling Pathway Anatomical Structure Development Ammonium Transmembrane Transport	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Cellular Hyperosmotic Salinity Response DNA-templated Transcription, Initiation Organ Development Response To Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signaling Multicellular Organismal Development Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Differentiation Viral Process Regulation Of Signal Transduction Anatomical Structure Development System Development
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Tagcloud (Difference) ?			achondroplasia attendant clefts collins craniosynostosis crest crouzon deformities dentofacial detoxifying excessively ganglionic hemifacial holoprosencephaly jaws kills malocclusions merging microsomia mismatches neuromeres ordinated palatal placodal placodes prominences radically shelves treacher
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