ATN1 and LTBP4

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATN1	LTBP4
Description		atrophin 1	latent transforming growth factor beta binding protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Perinuclear Region Of Cytoplasm Anchoring Junction	Microfibril Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding	Transforming Growth Factor Beta Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Growth Factor Binding Transforming Growth Factor Beta Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Killing Spermatogenesis Central Nervous System Development Determination Of Adult Lifespan Male Gonad Development Post-embryonic Development Cell Migration Maintenance Of Cell Polarity Response To Food Multicellular Organism Growth Positive Regulation Of DNA-templated Transcription Neuron Apoptotic Process	Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hormone Secretion Elastic Fiber Assembly
Pathways		Regulation of PTEN gene transcription	Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs
Drugs
Diseases		Dentatorubropallidoluysian atrophy (DRPLA)	Cutis laxa with severe pulmonary, gastrointestinal, and urinary abnormalities; Urban-Rifkin-Davis syndrome
GWAS		Refractive error ( 32231278)	Appendicular lean mass ( 33097823) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1/FVC) ( 26635082 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Red blood cell count ( 32888494)
Interacting Genes		126 interacting genes: AGRN ALG13 ARF3 ATRX BAG3 BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CHRD CPAP CRACR2A CRIP2 CSNK2A1 CTNND2 DGCR6L DMPK DMRT3 DVL1 DVL2 ECM1 EFEMP1 EFEMP2 ETNK2 EWSR1 FBLN1 FBLN2 FBLN5 FXR1 FXR2 GAPDH GCC1 GIGYF1 GRN HGS HINFP HNRNPF HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP12-2 KRTAP15-1 KRTAP19-2 KRTAP19-5 KRTAP4-12 KRTAP6-2 KRTAP9-3 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 OLIG3 P4HA3 PCSK5 PDCD6IP PFKL PIN1 PITX1 PITX2 PLSCR1 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBM14 RBM4B RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SAXO4 SH3RF1 SHANK3 SIAH1 SIAH2 SLC25A48 SLIT1 SPAG5 SS18L1 SSPOP STXBP4 SYVN1 TEKT3 TEP1 TLE1 TLE5 TNFAIP8 TRIP6 TSC1 USP2 USP54 VIM WDR5 WWP1 WWP2 YAP1 ZMYND8 ZNF503 ZSWIM8	16 interacting genes: ATN1 ATXN7 CACNA1A CRKL CRY1 CTDSP1 FBLN1 FRAT1 GFI1B HOXA1 ITSN2 MBD1 NUFIP2 RAC1 SHANK3 TGFB1
Entrez ID		1822	8425
HPRD ID		06311	05274
Ensembl ID		ENSG00000111676	ENSG00000090006
Uniprot IDs		P54259 Q86V38	A0A0C4DH07 B3KXY6 Q8N2S1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Developmental Process Extracellular Matrix Structural Constituent Positive Regulation Of Metabolic Process Regulation Of Gene Expression Calcium Ion Binding Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Protein Stabilization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Intermediate Filament Transcription Corepressor Activity Regulation Of Protein Stability Elastic Fiber Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway System Development Apoptotic Process DNA-binding Transcription Factor Binding Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Programmed Cell Death Cell Death Histone H3 Acetyltransferase Activity Regulation Of Cell Population Proliferation Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Projection Organization Signal Transduction Positive Regulation Of RNA Metabolic Process	Nuclear Matrix Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Interleukin-23 Production Postsynaptic Specialization Assembly Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Positive Regulation Of Cell-substrate Adhesion Postsynaptic Specialization Organization Regulation Of Leukocyte Migration Helper T Cell Diapedesis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Adhesion Regulation Of Cellular Localization Dendrite Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Migration Negative Regulation Of Metabolic Process Positive Regulation Of Cell Motility Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Central Nervous System Neuron Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Protein Localization To Membrane Regulation Of Cell-substrate Adhesion Establishment Or Maintenance Of Cell Polarity Blue Light Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Transformation Of Host Cell By Virus Cochlea Morphogenesis Semicircular Canal Formation Abducens Nerve Formation Inner Ear Development Optokinetic Behavior Positive Regulation Of Ovarian Follicle Development Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Interleukin-23 Production Negative Regulation Of Endocytosis Regulation Of Cell Development Regulation Of Fibroblast Migration Regulation Of ERK5 Cascade
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