GIGYF1 and FAM124B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GIGYF1	FAM124B
Description		GRB10 interacting GYF protein 1	family with sequence similarity 124 member B
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Insulin-like Growth Factor Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) LDL cholesterol ( 30275531) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Resting heart rate ( 27798624)	Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Familial squamous cell lung carcinoma ( 29924316)
Interacting Genes		33 interacting genes: AIRIM ANKRD10 ARMC7 ATN1 CBX8 CCDC57 CNOT9 CRACR2A ENKD1 FAM124B GRB10 GRB14 GRB7 KAT5 KIFC3 MCRS1 MNS1 NEK6 NFKBID PRKAA2 PRR35 RBM22 SCAF8 SCNM1 SMARCD1 SNRPB SNRPC SPAG8 STAC3 TCEA2 TLE5 TROAP TSHZ2	67 interacting genes: ABI1 ABI3 ADAMTSL4 BIRC7 BLZF1 CARD9 CCDC85B CYSRT1 DRC12 EFEMP2 EFHC2 ESM1 GIGYF1 GKAP1 GOLGA2 GPRASP2 GPRASP3 GRB7 HSF2BP IHO1 IKZF3 ISCA2 KCTD6 KCTD9 KIAA1958 KRT19 KRT31 KRT40 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 KRTAP9-3 LHX3 LZTS2 MBD3L1 MDFI MIPOL1 MKRN3 MTUS2 MYF5 NADK NOTCH2NLA RBPMS RINT1 RSPH3 SEPTIN14 SH2B2 SP7 SSX2IP TCF4 TLE5 TRAF2 TRIM37 TRIM42 TRIM54 TRIM8 TRIM9 TRIP6 USHBP1 USP54 WDR83 ZBED1 ZNF69 ZNF774 ZRANB1
Entrez ID		64599	79843
HPRD ID		10145	08663
Ensembl ID		ENSG00000146830	ENSG00000124019
Uniprot IDs		O75420	Q9H5Z6
PDB IDs		5NVK 7RUQ
Enriched GO Terms of Interacting Partners?		Nucleoplasm Spliceosomal Complex Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Positive Regulation Of DNA Repair Spindle Pole Protein Binding Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Insulin Receptor Signaling Pathway MRNA Splicing, Via Spliceosome U2-type Prespliceosome RNA Splicing U1 SnRNP Microtubule-based Process RNA Splicing, Via Transesterification Reactions Phosphatidylcholine Biosynthetic Process Regulation Of DNA Repair MRNA Metabolic Process Histone Acetyltransferase Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Cation Channel Activity	Identical Protein Binding Keratin Filament Intermediate Filament Protein Binding Ubiquitin Protein Ligase Activity Signaling Adaptor Activity Post-translational Protein Modification Cytoskeleton Protein Modification By Small Protein Conjugation Protein Ubiquitination
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