GIGYF1 and GRB10

Number of citations of the paper that reports this interaction (PMID 12771153)
14

Data Source:
HPRD (in vivo, two hybrid)

		GIGYF1	GRB10
Gene Name		GRB10 interacting GYF protein 1	growth factor receptor-bound protein 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Cytosol Plasma Membrane
	Molecular Function		SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding
	Biological Process	Insulin-like Growth Factor Receptor Signaling Pathway	Insulin Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Insulin Negative Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events SHC activation Signaling by Insulin receptor
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23512250) Bone mineral density ( 22504420) Fasting glucose-related traits (interaction with BMI) ( 22581228) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		4 interactors: ATN1 EIF4E2 GRB10 RQCD1	30 interactors: ABL1 AKT1 APP BCR DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET RQCD1 SRC ZDHHC17
Entrez ID		64599	2887
HPRD ID		10145	03312
Ensembl ID		ENSG00000146830	ENSG00000106070
Uniprot IDs		O75420	Q13322
PDB IDs			1NRV 3HK0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Cellular Response To Organic Substance Maintenance Of Cell Polarity Cytokine-mediated Signaling Pathway Posttranscriptional Regulation Of Gene Expression Toxin Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Glucose Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nuclear-transcribed MRNA Poly(A) Tail Shortening Response To Organic Substance Response To Cytokine Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Glycogen Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Neuron Apoptotic Process Regulation Of Metabolic Process Gene Silencing By RNA Regulation Of Insulin Receptor Signaling Pathway Regulation Of Glucose Import Gene Expression Neuron Death Negative Regulation Of Signal Transduction Cellular Macromolecule Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Macromolecule Biosynthetic Process MRNA 3'-end Processing Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Signaling Negative Regulation Of Translation Regulation Of Glucose Transport Gene Silencing Regulation Of Glucose Metabolic Process RNA 3'-end Processing	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Phosphorylation Cellular Response To Organic Substance Intracellular Signal Transduction Cellular Response To Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Migration ERBB Signaling Pathway Positive Regulation Of Cell Motility Peptidyl-amino Acid Modification Cellular Response To Organonitrogen Compound Positive Regulation Of Cellular Component Movement Signal Transduction Positive Regulation Of Locomotion Regulation Of Signaling Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Signaling Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Neurotrophin TRK Receptor Signaling Pathway Cell Communication Cellular Response To Peptide Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Response To Hormone Regulation Of Cell Migration Fibroblast Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Fc Receptor Signaling Pathway
Tagcloud ?		adapter binds bps cooperatively designated detectable dissociates domains fragment grb10 homologous homology hybrid interacting leaving links modulates motifs phosphotyrosine presumably proline tagged tandem terminus transfection transiently	becomes carries cytokine driven effector emerging exert fashion fos grbir homology hybrid insights interacting looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned
Tagcloud (Difference) ?		adapter binds bps cooperatively designated detectable dissociates domains fragment homologous leaving links modulates motifs phosphotyrosine presumably proline tagged tandem terminus transfection transiently	becomes carries cytokine driven effector emerging exert fashion fos grbir insights looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned
Tagcloud (Intersection) ?		grb10 homology hybrid interacting