GIGYF1 and GRB10

Number of citations of the paper that reports this interaction (PubMedID 12771153)
0

Data Source:
HPRD (in vivo, two hybrid)

		GIGYF1	GRB10
Description		GRB10 interacting GYF protein 1	growth factor receptor bound protein 10
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GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Insulin Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity Protein-macromolecule Adaptor Activity Identical Protein Binding
	Biological Process	Insulin-like Growth Factor Receptor Signaling Pathway	Signal Transduction Insulin Receptor Signaling Pathway Gene Expression Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Insulin Positive Regulation Of Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of Cold-induced Thermogenesis Vascular Associated Smooth Muscle Cell Migration
Pathways			Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling FLT3 Signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) LDL cholesterol ( 30275531) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Resting heart rate ( 27798624)	Acute lymphoblastic leukemia (childhood) ( 23512250) Age-related hearing impairment ( 34108613) Appendicular lean mass ( 33097823) Area under the curve of insulin levels ( 24699409) Birth weight ( 31043758) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Corpus callosum mid-anterior volume ( 31530798) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Femoral neck bone mineral density ( 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Incremental insulin ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia (treatment resistant) ( 25223841) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 21779181) Total body bone mineral density ( 29304378) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		33 interacting genes: AIRIM ANKRD10 ARMC7 ATN1 CBX8 CCDC57 CNOT9 CRACR2A ENKD1 FAM124B GRB10 GRB14 GRB7 KAT5 KIFC3 MCRS1 MNS1 NEK6 NFKBID PRKAA2 PRR35 RBM22 SCAF8 SCNM1 SMARCD1 SNRPB SNRPC SPAG8 STAC3 TCEA2 TLE5 TROAP TSHZ2	49 interacting genes: AANAT ABL1 AKT1 APP BAIAP2 BCR BLK CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 ERBB2 ERBB4 FARS2 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KANK2 KDR KIT KPNA3 MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NFKBID NOA1 PDGFRB PICK1 RAF1 RET SRC TEKT4 TEPSIN TNK1 TRIM55 TRIM63 TXK WEE2-AS1 ZDHHC17 ZMYND19
Entrez ID		64599	2887
HPRD ID		10145	03312
Ensembl ID		ENSG00000146830	ENSG00000106070
Uniprot IDs		O75420	A0A2R8YCL1 Q13322
PDB IDs		5NVK 7RUQ	1NRV 3HK0
Enriched GO Terms of Interacting Partners?		Nucleoplasm Spliceosomal Complex Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Positive Regulation Of DNA Repair Spindle Pole Protein Binding Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Insulin Receptor Signaling Pathway MRNA Splicing, Via Spliceosome U2-type Prespliceosome RNA Splicing U1 SnRNP Microtubule-based Process RNA Splicing, Via Transesterification Reactions Phosphatidylcholine Biosynthetic Process Regulation Of DNA Repair MRNA Metabolic Process Histone Acetyltransferase Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Cation Channel Activity	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Kinase Activity Protein Phosphorylation Phosphorylation Transferase Activity Insulin-like Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Modification Process Peptidyl-tyrosine Phosphorylation ATP Binding Nucleotide Binding Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Response To Growth Factor Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Protein Metabolic Process Receptor Complex Regulation Of Signaling Regulation Of Cell Communication Signal Transduction Regulation Of Signal Transduction Regulation Of Protein Modification Process Cellular Response To Growth Factor Stimulus Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Motility
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