GIGYF1 and CRACR2A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GIGYF1	CRACR2A
Description		GRB10 interacting GYF protein 1	calcium release activated channel regulator 2A
Image
GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Golgi Membrane Immunological Synapse Extracellular Region Cytoplasm Golgi Apparatus Microtubule Organizing Center Cytoskeleton Plasma Membrane Membrane Vesicle Trans-Golgi Network Membrane Weibel-Palade Body Specific Granule Lumen Specific Granule
	Molecular Function	Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Calcium Ion Binding Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Insulin-like Growth Factor Receptor Signaling Pathway	Store-operated Calcium Entry Adaptive Immune Response Immune System Process Monoatomic Ion Transport Calcium Ion Transport Intracellular Protein Localization Vesicle-mediated Transport Endosomal Transport Activation Of Store-operated Calcium Channel Activity Response To Histamine T-helper 1 Cell Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of Calcium Ion Transport
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) LDL cholesterol ( 30275531) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Resting heart rate ( 27798624)	Femur bone mineral density x serum urate levels interaction ( 34046847) Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		33 interacting genes: AIRIM ANKRD10 ARMC7 ATN1 CBX8 CCDC57 CNOT9 CRACR2A ENKD1 FAM124B GRB10 GRB14 GRB7 KAT5 KIFC3 MCRS1 MNS1 NEK6 NFKBID PRKAA2 PRR35 RBM22 SCAF8 SCNM1 SMARCD1 SNRPB SNRPC SPAG8 STAC3 TCEA2 TLE5 TROAP TSHZ2	35 interacting genes: ANKRD29 ASB3 ATN1 CCHCR1 CDC23 DDIT3 FAM156A FAM156B FAM86C1P FKBP6 GIGYF1 GOLGA2 KRT31 KRT75 KRTAP13-1 KRTAP19-5 LRIF1 MDFI MID2 MKRN3 NOTCH2NLA OIP5 PNMA5 POLR1C RBAK RORB SLAIN1 SORBS3 TLE5 TRAF1 TRIM29 USP2 ZC2HC1C ZNF20 ZNF655
Entrez ID		64599	84766
HPRD ID		10145	10079
Ensembl ID		ENSG00000146830	ENSG00000130038
Uniprot IDs		O75420	Q9BSW2
PDB IDs		5NVK 7RUQ	6PSD
Enriched GO Terms of Interacting Partners?		Nucleoplasm Spliceosomal Complex Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Positive Regulation Of DNA Repair Spindle Pole Protein Binding Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Insulin Receptor Signaling Pathway MRNA Splicing, Via Spliceosome U2-type Prespliceosome RNA Splicing U1 SnRNP Microtubule-based Process RNA Splicing, Via Transesterification Reactions Phosphatidylcholine Biosynthetic Process Regulation Of DNA Repair MRNA Metabolic Process Histone Acetyltransferase Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Cation Channel Activity	Identical Protein Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?