GIGYF1 and ATN1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GIGYF1	ATN1
Gene Name		GRB10 interacting GYF protein 1	atrophin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function		Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Toxin Receptor Binding
	Biological Process	Insulin-like Growth Factor Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Central Nervous System Development Toxin Metabolic Process Cell Migration Maintenance Of Cell Polarity Neuron Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ATN1 EIF4E2 GRB10 RQCD1	93 interactors: AES AGRN ALG13 ARF3 ATRX BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CENPJ CHRD CRACR2A CRIP2 CTNND2 DMPK DVL1 DVL2 ECM1 EFEMP1 EFEMP2 EWSR1 FBLN1 FBLN2 FBLN5 GAPDH GCC1 GIGYF1 GRN HINFP HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP4-12 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 PCSK5 PDCD6IP PFKL PLSCR1 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SIAH1 SIAH2 SLIT1 SPAG5 SSPO STXBP4 SYVN1 TEP1 TLE1 TRIP6 USP54 VIM WDR5 WWP1 WWP2 ZMYND8 ZSWIM8
Entrez ID		64599	1822
HPRD ID		10145	06311
Ensembl ID		ENSG00000146830	ENSG00000111676
Uniprot IDs		O75420	P54259 Q86V38
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Cellular Response To Organic Substance Maintenance Of Cell Polarity Cytokine-mediated Signaling Pathway Posttranscriptional Regulation Of Gene Expression Toxin Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Glucose Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nuclear-transcribed MRNA Poly(A) Tail Shortening Response To Organic Substance Response To Cytokine Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Glycogen Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Neuron Apoptotic Process Regulation Of Metabolic Process Gene Silencing By RNA Regulation Of Insulin Receptor Signaling Pathway Regulation Of Glucose Import Gene Expression Neuron Death Negative Regulation Of Signal Transduction Cellular Macromolecule Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Macromolecule Biosynthetic Process MRNA 3'-end Processing Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Signaling Negative Regulation Of Translation Regulation Of Glucose Transport Gene Silencing Regulation Of Glucose Metabolic Process RNA 3'-end Processing	Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Developmental Process Regulation Of Gene Expression Signaling Regulation Of Signaling Signal Transduction Nervous System Development Anatomical Structure Development Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Cellular Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Proteolysis Regulation Of RNA Biosynthetic Process System Development Response To Stimulus Cell Death Death Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Morphogenesis Modification-dependent Protein Catabolic Process Protein Catabolic Process Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Programmed Cell Death Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Biosynthetic Process Protein Ubiquitination Axon Development
Tagcloud ?		adapter binds bps cooperatively designated detectable dissociates domains fragment grb10 homologous homology hybrid interacting leaving links modulates motifs phosphotyrosine presumably proline tagged tandem terminus transfection transiently	atrophin1 atrophy chip cortical degenerative demethylase dentatorubral depletion h3k4 hint inducing knockout lbal lsd1 lysine maintenance methylation npc pallidoluysian phenocopied poorly precise premature progenitor repression rescued seq surprisingly tranylcypromine
Tagcloud (Difference) ?		adapter binds bps cooperatively designated detectable dissociates domains fragment grb10 homologous homology hybrid interacting leaving links modulates motifs phosphotyrosine presumably proline tagged tandem terminus transfection transiently	atrophin1 atrophy chip cortical degenerative demethylase dentatorubral depletion h3k4 hint inducing knockout lbal lsd1 lysine maintenance methylation npc pallidoluysian phenocopied poorly precise premature progenitor repression rescued seq surprisingly tranylcypromine
Tagcloud (Intersection) ?