GIGYF1 and CNOT9

Number of citations of the paper that reports this interaction (PubMedID 29395067)
0

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, pull down)

		GIGYF1	CNOT9
Description		GRB10 interacting GYF protein 1	CCR4-NOT transcription complex subunit 9
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GO Annotations	Cellular Component	Cytosol Protein-containing Complex	P-body Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex Protein-containing Complex
	Molecular Function	Protein Binding	Transcription Coactivator Activity Epidermal Growth Factor Receptor Binding Protein Binding Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Insulin-like Growth Factor Receptor Signaling Pathway	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Regulation Of Translation Sex Differentiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription
Pathways			Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) LDL cholesterol ( 30275531) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Resting heart rate ( 27798624)
Interacting Genes		33 interacting genes: AIRIM ANKRD10 ARMC7 ATN1 CBX8 CCDC57 CNOT9 CRACR2A ENKD1 FAM124B GRB10 GRB14 GRB7 KAT5 KIFC3 MCRS1 MNS1 NEK6 NFKBID PRKAA2 PRR35 RBM22 SCAF8 SCNM1 SMARCD1 SNRPB SNRPC SPAG8 STAC3 TCEA2 TLE5 TROAP TSHZ2	11 interacting genes: AKT1 EGFR GADD45A GADD45B GADD45G GIGYF1 GIGYF2 GRB10 MESD MYB OBI1
Entrez ID		64599	9125
HPRD ID		10145	08828
Ensembl ID		ENSG00000146830	ENSG00000144580
Uniprot IDs		O75420	D5MQE1 Q92600
PDB IDs		5NVK 7RUQ	2FV2 4CRU 4CRV 4CT6 4CT7 5LSW 5ONA 5ONB 6HOM 6HON 9FL8
Enriched GO Terms of Interacting Partners?		Nucleoplasm Spliceosomal Complex Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Positive Regulation Of DNA Repair Spindle Pole Protein Binding Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Insulin Receptor Signaling Pathway MRNA Splicing, Via Spliceosome U2-type Prespliceosome RNA Splicing U1 SnRNP Microtubule-based Process RNA Splicing, Via Transesterification Reactions Phosphatidylcholine Biosynthetic Process Regulation Of DNA Repair MRNA Metabolic Process Histone Acetyltransferase Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Cation Channel Activity	Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of P38MAPK Cascade Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of P38MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Localization To Membrane Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Cycle Enzyme-linked Receptor Protein Signaling Pathway Response To UV-A Kinase Binding Positive Regulation Of JNK Cascade Protein-containing Complex Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Apoptotic Process Regulation Of JNK Cascade Regulation Of G1/S Transition Of Mitotic Cell Cycle Embryonic Organ Development Regulation Of Programmed Cell Death Regulation Of Glycogen Biosynthetic Process Regulation Of Protein Localization To Membrane Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Apoptotic Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Translational Initiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Epidermal Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Fibroblast Proliferation Positive Regulation Of MiRNA Transcription Regulation Of TRNA Methylation Regulation Of D-glucose Import Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Multivesicular Body, Internal Vesicle Lumen Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Epidermal Growth Factor Receptor Signaling Pathway
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