GIGYF1 and SCAF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GIGYF1	SCAF8
Description		GRB10 interacting GYF protein 1	SR-related CTD associated factor 8
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GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage Factor Complex Nuclear Matrix
	Molecular Function	Protein Binding	RNA Polymerase II Complex Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RNA Polymerase Core Enzyme Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding
	Biological Process	Insulin-like Growth Factor Receptor Signaling Pathway	Termination Of RNA Polymerase II Transcription Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
Pathways
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) LDL cholesterol ( 30275531) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Resting heart rate ( 27798624)	Asthma ( 32296059) Bisphosphonate-associated atypical femoral fracture ( 31006051) Colorectal or endometrial cancer ( 26621817) Daytime nap ( 33568662) Diabetic kidney disease ( 26305897) Estimated glomerular filtration rate ( 31152163) Lipoprotein (a) levels ( 26377243)
Interacting Genes		33 interacting genes: AIRIM ANKRD10 ARMC7 ATN1 CBX8 CCDC57 CNOT9 CRACR2A ENKD1 FAM124B GRB10 GRB14 GRB7 KAT5 KIFC3 MCRS1 MNS1 NEK6 NFKBID PRKAA2 PRR35 RBM22 SCAF8 SCNM1 SMARCD1 SNRPB SNRPC SPAG8 STAC3 TCEA2 TLE5 TROAP TSHZ2	4 interacting genes: GIGYF1 GOLGA2 RNF10 TEX11
Entrez ID		64599	22828
HPRD ID		10145	11487
Ensembl ID		ENSG00000146830	ENSG00000213079
Uniprot IDs		O75420	A0A0A0MT33 B7Z3A4 B7Z876 Q9UPN6
PDB IDs		5NVK 7RUQ	2DIW 3D9I 3D9J 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P
Enriched GO Terms of Interacting Partners?		Nucleoplasm Spliceosomal Complex Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Positive Regulation Of DNA Repair Spindle Pole Protein Binding Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Insulin Receptor Signaling Pathway MRNA Splicing, Via Spliceosome U2-type Prespliceosome RNA Splicing U1 SnRNP Microtubule-based Process RNA Splicing, Via Transesterification Reactions Phosphatidylcholine Biosynthetic Process Regulation Of DNA Repair MRNA Metabolic Process Histone Acetyltransferase Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Cation Channel Activity	Positive Regulation Of Protein Glycosylation Regulation Of Protein Glycosylation Importin-alpha Family Protein Binding Golgi Disassembly Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Gene Conversion Central Element Male Meiosis Chromosome Segregation Meiotic Gene Conversion Chiasma Assembly Golgi Cis Cisterna Golgi Ribbon Formation Asymmetric Cell Division Meiotic Chromosome Segregation Positive Regulation Of Glycoprotein Biosynthetic Process Meiotic Spindle Assembly Negative Regulation Of Glial Cell Proliferation Resolution Of Meiotic Recombination Intermediates Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Glycoprotein Metabolic Process Meiotic Spindle Organization Positive Regulation Of Myelination Programmed Cell Death Involved In Cell Development Synaptonemal Complex Assembly Synaptonemal Complex Synaptonemal Complex Organization Reciprocal Meiotic Recombination Negative Regulation Of Protein Binding Microtubule Nucleation
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