PTPRO and SH3GL3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PTPRO	SH3GL3
Gene Name		protein tyrosine phosphatase, receptor type, O	SH3-domain GRB2-like 3
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Lamellipodium Axon Growth Cone Neuron Projection Dendritic Spine Extracellular Vesicular Exosome	Early Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Phosphatase Activity Wnt-protein Binding Protein Homodimerization Activity	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis Monocyte Chemotaxis Regulation Of Glomerular Filtration Negative Regulation Of Glomerular Filtration Protein Dephosphorylation Axon Guidance Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Lamellipodium Assembly Glomerulus Development Peptidyl-tyrosine Dephosphorylation Slit Diaphragm Assembly Glomerular Visceral Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retinal Ganglion Cell Axon Guidance	Endocytosis Signal Transduction Central Nervous System Development
Pathways
Drugs
Diseases
GWAS		Cognitive function ( 22126837)	Height ( 18391950 18391951 20397748)
Protein-Protein Interactions		9 interactors: ACTG1 APP DPPA4 DPYSL4 KIT PIM1 SH3GL1 SH3GL3 YWHAZ	44 interactors: ADRB1 AES ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNM1 DPPA4 DPYSL4 EGFL6 EMD FAM173A FASLG GABBR2 HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RBM48 RER1 RPL35A SEPT8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TNNT1 TOE1 VIM WASL WDR33
Entrez ID		5800	6457
HPRD ID		02784	04528
Ensembl ID		ENSG00000151490	ENSG00000140600
Uniprot IDs		Q16827	Q99963
PDB IDs		2G59 2GJT	2EW3 2Z0V
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Multicellular Organismal Development Mast Cell Degranulation Mast Cell Mediated Immunity Platelet Activation Lysosome Localization Chemotaxis Mast Cell Activation Nervous System Development Developmental Process Endocytosis Cell Activation Leukocyte Degranulation System Development Regulated Secretory Pathway Exocytosis Visual Learning Visual Behavior Axon Guidance Programmed Cell Death Anatomical Structure Development Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Cell Death Death Blood Coagulation Associative Learning Hemostasis Cell Projection Organization Secretion By Cell Synaptic Growth At Neuromuscular Junction Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Locomotion Axonogenesis Immune Response Defense Response Axon Development Regulation Of Body Fluid Levels Collateral Sprouting In Absence Of Injury Mast Cell Differentiation Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Learning Secretion Leukocyte Activation Involved In Immune Response Neuron Projection Morphogenesis Mast Cell Chemotaxis	Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Regulation Of ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Signaling Signal Transduction Vesicle-mediated Transport Cell Communication Movement Of Cell Or Subcellular Component Regulation Of Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Cell Death Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Membrane Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process System Development Neuron Development Apoptotic Process Cellular Process Generation Of Neurons Actin Filament-based Movement Multicellular Organismal Development Nervous System Development Programmed Cell Death Regulation Of Signaling Neurogenesis Regulation Of Endocytosis Regulation Of Signal Transduction Negative Regulation Of Neuron Differentiation Neuron Projection Development Establishment Of Vesicle Localization Synaptic Transmission Positive Regulation Of Apoptotic Process Cell Projection Morphogenesis Neuron Differentiation Vesicle Localization Response To Growth Factor Axon Guidance Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis
Tagcloud ?		3beta acts attenuated axis cascade catenin clearly con confer equally erbb2 fh fulminant gsk hepatitis hepatocytes importantly intriguingly investigations knockout ko liver marked nk nkt phosphatase potentiated responded secretion	85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish
Tagcloud (Difference) ?		3beta acts attenuated axis cascade catenin clearly con confer equally erbb2 fh fulminant gsk hepatitis hepatocytes importantly intriguingly investigations knockout ko liver marked nk nkt phosphatase potentiated responded secretion	85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish
Tagcloud (Intersection) ?