PTPRO and ACTG1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PTPRO	ACTG1
Gene Name		protein tyrosine phosphatase, receptor type, O	actin gamma 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Lamellipodium Axon Growth Cone Neuron Projection Dendritic Spine Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Phosphatase Activity Wnt-protein Binding Protein Homodimerization Activity	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis Monocyte Chemotaxis Regulation Of Glomerular Filtration Negative Regulation Of Glomerular Filtration Protein Dephosphorylation Axon Guidance Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Lamellipodium Assembly Glomerulus Development Peptidyl-tyrosine Dephosphorylation Slit Diaphragm Assembly Glomerular Visceral Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retinal Ganglion Cell Axon Guidance	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation
Pathways			Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Cognitive function ( 22126837)
Protein-Protein Interactions		9 interactors: ACTG1 APP DPPA4 DPYSL4 KIT PIM1 SH3GL1 SH3GL3 YWHAZ	60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1
Entrez ID		5800	71
HPRD ID		02784	00017
Ensembl ID		ENSG00000151490	ENSG00000184009
Uniprot IDs		Q16827	P63261
PDB IDs		2G59 2GJT
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Multicellular Organismal Development Mast Cell Degranulation Mast Cell Mediated Immunity Platelet Activation Lysosome Localization Chemotaxis Mast Cell Activation Nervous System Development Developmental Process Endocytosis Cell Activation Leukocyte Degranulation System Development Regulated Secretory Pathway Exocytosis Visual Learning Visual Behavior Axon Guidance Programmed Cell Death Anatomical Structure Development Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Cell Death Death Blood Coagulation Associative Learning Hemostasis Cell Projection Organization Secretion By Cell Synaptic Growth At Neuromuscular Junction Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Locomotion Axonogenesis Immune Response Defense Response Axon Development Regulation Of Body Fluid Levels Collateral Sprouting In Absence Of Injury Mast Cell Differentiation Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Learning Secretion Leukocyte Activation Involved In Immune Response Neuron Projection Morphogenesis Mast Cell Chemotaxis	Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction
Tagcloud ?		3beta acts attenuated axis cascade catenin clearly con confer equally erbb2 fh fulminant gsk hepatitis hepatocytes importantly intriguingly investigations knockout ko liver marked nk nkt phosphatase potentiated responded secretion	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		3beta acts attenuated axis cascade catenin clearly con confer equally erbb2 fh fulminant gsk hepatitis hepatocytes importantly intriguingly investigations knockout ko liver marked nk nkt phosphatase potentiated responded secretion	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?