PTPRO and DPPA4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PTPRO	DPPA4
Description		protein tyrosine phosphatase receptor type O	developmental pluripotency associated 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Lamellipodium Axon Growth Cone Neuron Projection Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse	Nucleus Nucleoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Wnt-protein Binding Protein Homodimerization Activity Cadherin Binding	Chromatin Binding Protein Binding
	Biological Process	Cell Morphogenesis Monocyte Chemotaxis Regulation Of Glomerular Filtration Negative Regulation Of Glomerular Filtration Axon Guidance Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Lamellipodium Assembly Glomerulus Development Slit Diaphragm Assembly Regulation Of Synapse Organization Podocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retinal Ganglion Cell Axon Guidance	System Development Lung-associated Mesenchyme Development
Pathways		Signaling by NTRK3 (TRKC)	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS		Cognitive function ( 22126837) General cognitive ability ( 29844566) Glomerular filtration rate (creatinine) ( 26831199) Homeostasis model assessment of insulin resistance ( 33381925) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Intelligence (MTAG) ( 29326435) Metamizole-induced agranulocytosis or neutropenia ( 33138277) Obstetric antiphospholipid syndrome ( 28424481) Temporal pole volume ( 31530798)	Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: ACTG1 APP DPPA4 DPYSL4 KIT PIM1 SH3GL1 SH3GL3 UFL1 YWHAZ	37 interacting genes: BTBD2 CIRSR CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAP1LC3A MAP1LC3B MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM
Entrez ID		5800	55211
HPRD ID		02784	16836
Ensembl ID		ENSG00000151490	ENSG00000121570
Uniprot IDs		Q16827	Q7L190
PDB IDs		2G59 2GJT
Enriched GO Terms of Interacting Partners?		Basal Body Patch Regulation Of Endocytosis Developmental Process Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Presynapse Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Myeloid Cell Development System Development Central Nervous System Development Regulation Of Long-term Neuronal Synaptic Plasticity Visual Behavior Regulation Of Immune Response Regulation Of Response To Calcium Ion Early Endosome Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Defense Response Defense Response To Bacterium Neuron Recognition Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Negative Regulation Of Immune Response Negative Regulation Of TORC1 Signaling Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cardioblast Proliferation UFM1 Ligase Activity Cellular Response To Type II Interferon Erythrocyte Differentiation Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Defense Response Cellular Component Assembly Acetylcholine Receptor Activator Activity Regulation Of Immune System Process Regulation Of Cell Differentiation Regulation Of Developmental Process Positive Regulation Of Neuron Differentiation Lipoprotein Particle Positive Regulation Of Protein Import Phosphorylation Negative Regulation Of TOR Signaling	Phosphotyrosine Residue Binding Cytoplasm Protein Binding Cellular Response To Muramyl Dipeptide Cellular Response To Nitrogen Starvation Cleavage Furrow Formation Import Into Cell Endocytosis Central Nervous System Development Phosphatidylethanolamine Binding Plasma Membrane Tubulation Organelle Organization Spindle Pole Centrosome
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