PTPRO and DPPA4

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PTPRO	DPPA4
Gene Name		protein tyrosine phosphatase, receptor type, O	developmental pluripotency associated 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Lamellipodium Axon Growth Cone Neuron Projection Dendritic Spine Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Phosphatase Activity Wnt-protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Cell Morphogenesis Monocyte Chemotaxis Regulation Of Glomerular Filtration Negative Regulation Of Glomerular Filtration Protein Dephosphorylation Axon Guidance Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Lamellipodium Assembly Glomerulus Development Peptidyl-tyrosine Dephosphorylation Slit Diaphragm Assembly Glomerular Visceral Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retinal Ganglion Cell Axon Guidance	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Lung-associated Mesenchyme Development
Pathways
Drugs
Diseases
GWAS		Cognitive function ( 22126837)	Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726)
Protein-Protein Interactions		9 interactors: ACTG1 APP DPPA4 DPYSL4 KIT PIM1 SH3GL1 SH3GL3 YWHAZ	17 interactors: BTBD2 CRK DPPA2 EIF4A2 EMD GRB2 HTT LDOC1 MAPK6 PTPRO QARS RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 VIM
Entrez ID		5800	55211
HPRD ID		02784	16836
Ensembl ID		ENSG00000151490	ENSG00000121570
Uniprot IDs		Q16827	Q7L190
PDB IDs		2G59 2GJT
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Multicellular Organismal Development Mast Cell Degranulation Mast Cell Mediated Immunity Platelet Activation Lysosome Localization Chemotaxis Mast Cell Activation Nervous System Development Developmental Process Endocytosis Cell Activation Leukocyte Degranulation System Development Regulated Secretory Pathway Exocytosis Visual Learning Visual Behavior Axon Guidance Programmed Cell Death Anatomical Structure Development Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Cell Death Death Blood Coagulation Associative Learning Hemostasis Cell Projection Organization Secretion By Cell Synaptic Growth At Neuromuscular Junction Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Locomotion Axonogenesis Immune Response Defense Response Axon Development Regulation Of Body Fluid Levels Collateral Sprouting In Absence Of Injury Mast Cell Differentiation Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Learning Secretion Leukocyte Activation Involved In Immune Response Neuron Projection Morphogenesis Mast Cell Chemotaxis See more	Nervous System Development Anatomical Structure Development Cell Development System Development Response To Organic Substance Cellular Response To Organic Substance Cellular Response To Stimulus Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Central Nervous System Development Cellular Response To Growth Factor Stimulus Multicellular Organismal Development Response To Growth Factor Endocytosis Tissue Development Signal Transduction Cell Differentiation Insulin Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Organonitrogen Compound Vesicle-mediated Transport Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Regulation Of Cellular Process Negative Regulation Of Neuron Differentiation Response To Hormone Organ Development Neuron Development Generation Of Neurons Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Muscle Contraction Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurogenesis Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Signal Transduction Neuron Differentiation Muscle System Process Neural Plate Formation Glutaminyl-tRNA Aminoacylation Negative Regulation Of RNA-directed RNA Polymerase Activity Slit Diaphragm Assembly Regulation Of Translation Negative Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation See more
Tagcloud ?		3beta acts attenuated axis cascade catenin clearly con confer equally erbb2 fh fulminant gsk hepatitis hepatocytes importantly intriguingly investigations knockout ko liver marked nk nkt phosphatase potentiated responded secretion	assembled binds biochemical chromatin developmental digestion dynamics embryonic es frap h1 h3 histone immunoprecipitation implies micrococcal mnase mobility modulates nuclease nuclei photobleaching pluripotency poorly proper recovery truncated uncharacterized understood
Tagcloud (Difference) ?		3beta acts attenuated axis cascade catenin clearly con confer equally erbb2 fh fulminant gsk hepatitis hepatocytes importantly intriguingly investigations knockout ko liver marked nk nkt phosphatase potentiated responded secretion	assembled binds biochemical chromatin developmental digestion dynamics embryonic es frap h1 h3 histone immunoprecipitation implies micrococcal mnase mobility modulates nuclease nuclei photobleaching pluripotency poorly proper recovery truncated uncharacterized understood
Tagcloud (Intersection) ?