DPYSL4 and TRIP13

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DPYSL4	TRIP13
Description		dihydropyrimidinase like 4	thyroid hormone receptor interactor 13
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Male Germ Cell Nucleus Nucleus Chromosome
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding	Nucleotide Binding Transcription Coregulator Activity Protein Binding ATP Binding ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Nervous System Development	Oocyte Maturation Double-strand Break Repair Transcription By RNA Polymerase II Mitotic Spindle Assembly Checkpoint Signaling Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis I Female Meiosis I Spermatogenesis Spermatid Development Cell Differentiation Oogenesis Meiotic Cell Cycle Meiotic Recombination Checkpoint Signaling
Pathways		CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Pancreatic cancer ( 25086665)
Interacting Genes		9 interacting genes: DPYSL5 PTPRO RBPMS SH3GL1 SH3GL2 SH3GL3 TRIM54 TRIP13 WEE2-AS1	113 interacting genes: ACTMAP ADAM15 AMDHD2 ANKRD10 ARL11 ARSA ASB13 BKGD BUB1B C4orf33 CARD14 CD99 CDC20 CDIN1 CEP170B CFP CLIP4 COMT CRMP1 CRYBA2 CYB5R2 DCTN3 DDAH2 DIP2A DPYSL4 DTX2 EEF2KMT FBLN5 FBXO8 FILNC1 FNDC3B GALT GLYCTK GPRIN2 GPSM1 HDHD3 IGFN1 IL2RB INCA1 INTS11 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LNX1 LOXL4 LRR1 LRRC61 M1AP MAD2L1 MAD2L1BP MBLAC1 MEAK7 METTL15 MGAT5B MORN3 MPPED2 MVP MYEOV NIF3L1 NME4 NTAQ1 PARP11 PAX9 PBLD PCMTD2 PCSK5 PELI1 PLAC8 PLK3 PLSCR3 PLSCR4 POLR2L PPP2CA PRKAA2 PRKN PRR13 PSMB8 QARS1 RBPMS RHOXF2 RNF4 SCP2 SDCBP SEC24A SELENBP1 SEMA3B SEMA4G SHARPIN SIGLEC5 SMUG1 SPMIP9 SPRYD7 SSC4D STAMBP STAMBPL1 SUMO2 TENT5B THRB TINAGL1 TNRC6A TPT1 UBE2I VDR VENTX ZMYM5 ZNF34 ZNF655
Entrez ID		10570	9319
HPRD ID		07463	05145
Ensembl ID		ENSG00000151640	ENSG00000071539
Uniprot IDs		O14531	Q15645
PDB IDs		5NKS	5VQ9 5VQA 5WC2 6F0X 6LK0 7L9P
Enriched GO Terms of Interacting Partners?		Glutamatergic Synapse Negative Regulation Of Cellular Component Organization Central Nervous System Development Presynapse Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Glomerular Filtration Negative Regulation Of Retinal Ganglion Cell Axon Guidance Filtration Diaphragm Assembly Slit Diaphragm Assembly Lipid Binding Signal Transduction Endocytosis Identical Protein Binding System Development Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Clathrin-dependent Endocytosis Meiotic Recombination Checkpoint Signaling MRNA CDS Binding Pre-mRNA 5'-splice Site Binding Postsynaptic Endosome	Protein Binding Mitotic Checkpoint Complex Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Protein K6-linked Ubiquitination Intermediate Filament
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