DPYSL4 and SH3GL3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DPYSL4	SH3GL3
Gene Name		dihydropyrimidinase-like 4	SH3-domain GRB2-like 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Early Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance	Endocytosis Signal Transduction Central Nervous System Development
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS			Height ( 18391950 18391951 20397748)
Protein-Protein Interactions		8 interactors: DPYSL2 DPYSL5 PTPRO RBPMS SH3GL1 SH3GL2 SH3GL3 TRIP13	44 interactors: ADRB1 AES ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNM1 DPPA4 DPYSL4 EGFL6 EMD FAM173A FASLG GABBR2 HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RBM48 RER1 RPL35A SEPT8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TNNT1 TOE1 VIM WASL WDR33
Entrez ID		10570	6457
HPRD ID		07463	04528
Ensembl ID		ENSG00000151640	ENSG00000140600
Uniprot IDs		D3DRG7 O14531	Q99963
PDB IDs			2EW3 2Z0V
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Catabolic Process Axon Guidance Axonogenesis Nervous System Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Endocytosis Cell Morphogenesis Involved In Differentiation Pyrimidine Nucleobase Metabolic Process Neuron Projection Development Cell Projection Morphogenesis Anatomical Structure Development Cell Part Morphogenesis Cell Development Neuron Development Central Nervous System Development Developmental Process Cell Morphogenesis Neuron Differentiation Cell Projection Organization Slit Diaphragm Assembly Locomotion Synaptic Vesicle Transport System Development Negative Regulation Of Retinal Ganglion Cell Axon Guidance Vesicle-mediated Transport Cellular Response To Stimulus Movement Of Cell Or Subcellular Component Generation Of Neurons Multicellular Organismal Development Neurogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Glutamate Secretion Response To External Stimulus Negative Regulation Of Glomerular Filtration Establishment Of Vesicle Localization Signal Transduction Vesicle Localization Cell Differentiation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Signaling Response To Stimulus Cell Communication Positive Regulation Of Amino Acid Transport Regulation Of Cellular Process Regulation Of Glutamate Secretion Regulation Of Glomerular Filtration Positive Regulation Of SMAD Protein Import Into Nucleus	Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Regulation Of ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Signaling Signal Transduction Vesicle-mediated Transport Cell Communication Movement Of Cell Or Subcellular Component Regulation Of Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Cell Death Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Membrane Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process System Development Neuron Development Apoptotic Process Cellular Process Generation Of Neurons Actin Filament-based Movement Multicellular Organismal Development Nervous System Development Programmed Cell Death Regulation Of Signaling Neurogenesis Regulation Of Endocytosis Regulation Of Signal Transduction Negative Regulation Of Neuron Differentiation Neuron Projection Development Establishment Of Vesicle Localization Synaptic Transmission Positive Regulation Of Apoptotic Process Cell Projection Morphogenesis Neuron Differentiation Vesicle Localization Response To Growth Factor Axon Guidance Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis
Tagcloud ?			85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish
Tagcloud (Difference) ?			85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish
Tagcloud (Intersection) ?