DPYSL4 and SH3GL2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DPYSL4	SH3GL2
Gene Name		dihydropyrimidinase-like 4	SH3-domain GRB2-like 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling	Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS			Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)
Protein-Protein Interactions		8 interactors: DPYSL2 DPYSL5 PTPRO RBPMS SH3GL1 SH3GL2 SH3GL3 TRIP13	53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		10570	6456
HPRD ID		07463	05125
Ensembl ID		ENSG00000151640	ENSG00000107295
Uniprot IDs		D3DRG7 O14531	B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962
PDB IDs			1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Catabolic Process Axon Guidance Axonogenesis Nervous System Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Endocytosis Cell Morphogenesis Involved In Differentiation Pyrimidine Nucleobase Metabolic Process Neuron Projection Development Cell Projection Morphogenesis Anatomical Structure Development Cell Part Morphogenesis Cell Development Neuron Development Central Nervous System Development Developmental Process Cell Morphogenesis Neuron Differentiation Cell Projection Organization Slit Diaphragm Assembly Locomotion Synaptic Vesicle Transport System Development Negative Regulation Of Retinal Ganglion Cell Axon Guidance Vesicle-mediated Transport Cellular Response To Stimulus Movement Of Cell Or Subcellular Component Generation Of Neurons Multicellular Organismal Development Neurogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Glutamate Secretion Response To External Stimulus Negative Regulation Of Glomerular Filtration Establishment Of Vesicle Localization Signal Transduction Vesicle Localization Cell Differentiation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Signaling Response To Stimulus Cell Communication Positive Regulation Of Amino Acid Transport Regulation Of Cellular Process Regulation Of Glutamate Secretion Regulation Of Glomerular Filtration Positive Regulation Of SMAD Protein Import Into Nucleus	Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process
Tagcloud ?			250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Difference) ?			250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Intersection) ?