SCG5 and KHDRBS1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SCG5	KHDRBS1
Gene Name		secretogranin V (7B2 protein)	KH domain containing, RNA binding, signal transduction associated 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Secretory Granule	Nucleus Nucleoplasm Cytoplasm Membrane Grb2-Sos Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding GTP Binding Unfolded Protein Binding	DNA Binding RNA Binding SH3/SH2 Adaptor Activity Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Intracellular Protein Transport Neuropeptide Signaling Pathway Peptide Hormone Processing Negative Regulation Of Catalytic Activity Regulation Of Hormone Secretion	G2/M Transition Of Mitotic Cell Cycle Transcription, DNA-templated MRNA Processing Cell Cycle Arrest Signal Transduction Cell Surface Receptor Signaling Pathway Cell Proliferation Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus
Pathways
Drugs
Diseases
GWAS		Colorectal cancer ( 21761138) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: KHDRBS1 NR1H2 PCSK2 UBQLN1 UBQLN4	109 interactors: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK BZRAP1 CBL CD2AP CDK1 CIRBP CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 EFEMP1 EMG1 FGR FNBP4 FRK FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MIA2 MPP6 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OSTF1 PACSIN1 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RBMX RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SSFA2 STAT3 STUB1 TBL1X TJP1 TNFSF11 TUBB3 U2AF2 UBA52 UBASH3B VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6
Entrez ID		6447	10657
HPRD ID		01410	03926
Ensembl ID		ENSG00000166922	ENSG00000121774
Uniprot IDs		C9J650 P05408	Q07666
PDB IDs			2XA6 3QHE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Enkephalin Processing Islet Amyloid Polypeptide Processing Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of RNA Export From Nucleus Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Insulin Processing Positive Regulation Of Digestive System Process Protein Autoprocessing Insulin Metabolic Process Regulation Of RNA Export From Nucleus Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Translational Initiation Regulation Of Cholesterol Homeostasis Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lipid Storage Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Regulation Of Proteolysis Peptide Hormone Processing Regulation Of Cholesterol Transport Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Transport Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Endocytosis Regulation Of Cellular Response To Oxidative Stress Regulation Of Lipid Storage Positive Regulation Of Lipid Transport Positive Regulation Of Lipid Biosynthetic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Peptidyl-tyrosine Autophosphorylation Innate Immune Response Signal Transduction Immune Response-regulating Signaling Pathway Immune Response Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Locomotion Movement Of Cell Or Subcellular Component Cellular Response To Stimulus Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of Immune System Process Cellular Response To Peptide Hormone Stimulus Neurotrophin TRK Receptor Signaling Pathway Phagocytosis Cellular Response To Peptide Positive Regulation Of Immune System Process Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Antigen Receptor-mediated Signaling Pathway Cell Differentiation Regulation Of Catalytic Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Component Organization Immune System Process Response To Stimulus Regulation Of Signaling Cell Projection Organization Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Metabolic Process
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