SCG5 and PCSK2

Number of citations of the paper that reports this interaction (PubMedID 11439082)
171

Data Source:
HPRD (in vitro, in vivo)

		SCG5	PCSK2
Description		secretogranin V	proprotein convertase subtilisin/kexin type 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Secretory Granule	Extracellular Region Extracellular Space Nucleoplasm Membrane Transport Vesicle Secretory Granule Cytoplasmic Vesicle Neuron Projection Intracellular Organelle Lumen
	Molecular Function	Enzyme Inhibitor Activity Protein Binding GTP Binding Enzyme Regulator Activity Unfolded Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Intracellular Protein Transport Neuropeptide Signaling Pathway Peptide Hormone Processing Regulation Of Hormone Secretion	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing
Pathways			Insulin processing
Drugs
Diseases
GWAS		A body shape index ( 34021172) Chin dimples ( 27182965) Colorectal cancer ( 21761138 24737748 25990418 30529582 31826910) Obesity-related traits ( 23251661) Waist circumference adjusted for body mass index ( 34021172)	Biochemical measures ( 19260141) Body size at age 10 ( 32376654) Chronotype ( 30696823) Dialysis-related mortality ( 21546767) Familial lung cancer ( 29924316) Loneliness ( 27629369) Menarche (age at onset) ( 21102462 25231870) Morning person ( 30696823) Obesity-related traits ( 23251661) Preschool internalizing problems ( 24839885) Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		10 interacting genes: AGTR1 CCR2 FBXL17 KHDRBS1 MEOX2 NR1H2 PCSK2 UBQLN1 UBQLN2 UBQLN4	3 interacting genes: IAPP PMCH SCG5
Entrez ID		6447	5126
HPRD ID		01410	01202
Ensembl ID		ENSG00000166922	ENSG00000125851
Uniprot IDs		C9J650 C9JNY7 P05408	P16519
PDB IDs
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Proteolysis Positive Regulation Of ERAD Pathway Negative Regulation Of Transport Regulation Of Transport Regulation Of ERAD Pathway Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cellular Response To Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Ubiquitin-dependent Protein Catabolic Process Proteolysis Angiotensin Type I Receptor Activity Islet Amyloid Polypeptide Processing Positive Regulation Of Secretion Of Lysosomal Enzymes Grb2-Sos Complex Autophagy Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Negative Regulation Of Endocytosis Positive Regulation Of Metabolic Process Regulation Of Defense Response Bradykinin Receptor Binding Cytoplasmic Vesicle Enkephalin Processing Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagy Nuclear Proteasome Complex Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis ERAD Pathway Autophagosome Assembly Regulation Of Inflammatory Response	G Protein-coupled Receptor Signaling Pathway Hormone Activity Feeding Behavior Neuropeptide Signaling Pathway Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Negative Regulation Of Synaptic Transmission, Dopaminergic Amylin Receptor 3 Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor Signaling Pathway Regulation Of Synaptic Transmission, Dopaminergic Calcitonin Family Receptor Signaling Pathway Extracellular Region Negative Regulation Of Amyloid Fibril Formation Cell-cell Signaling Inclusion Body Negative Regulation Of Bone Resorption Regulation Of Amyloid Fibril Formation Negative Regulation Of Bone Remodeling Positive Regulation Of CAMP/PKA Signal Transduction Signaling Bone Resorption Cell Communication Amyloid Fibril Formation Enzyme Regulator Activity Eating Behavior Negative Regulation Of Osteoclast Differentiation Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication Regulation Of Bone Remodeling Osteoclast Differentiation Regulation Of Bone Resorption Sensory Perception Of Pain Regulation Of Signaling Negative Regulation Of Synaptic Transmission Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Calcium-mediated Signaling Protein Destabilization Enzyme Inhibitor Activity
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