SUDS3 and BRMS1

Number of citations of the paper that reports this interaction (PubMedID 16919237)
49

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		SUDS3	BRMS1
Description		SIN3A corepressor complex component SDS3	BRMS1 transcriptional repressor and anoikis regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Sin3-type Complex	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	Histone Deacetylase Activity Protein Binding Enzyme Binding Histone Deacetylase Binding	Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Apoptotic Process Regulation Of Gene Expression Substantia Nigra Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Protein Deacetylation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Anoikis
Pathways		HDACs deacetylate histones NoRC negatively regulates rRNA expression Ub-specific processing proteases Potential therapeutics for SARS	HDACs deacetylate histones Potential therapeutics for SARS
Drugs
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal sclerosis ( 25188341) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		7 interacting genes: BRMS1 CSNK2A1 GOLGA2 HDAC1 LDOC1 PTEN SRPK1	50 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SRC SUDS3 TAF1 THRSP UBE2D1
Entrez ID		64426	25855
HPRD ID		12196	05879
Ensembl ID		ENSG00000111707	ENSG00000174744
Uniprot IDs		Q9H7L9	G5E9I4 Q9HCU9
PDB IDs			2XUS 4AUV
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Cell Death Programmed Cell Death Apoptotic Process Meiotic Spindle Organization Meiotic Spindle Assembly Negative Regulation Of Stem Cell Population Maintenance NF-kappaB Binding Rhythmic Process Membraneless Organelle Assembly Organelle Assembly Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Motility Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Metabolic Process Spindle Assembly Enzyme Binding Krueppel-associated Box Domain Binding Negative Regulation Of Locomotion Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Collagen Type VI Trimer Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body PML Body Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Lysine Delactylase Activity Fungiform Papilla Formation Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Positive Regulation Of Protein Deacetylation Negative Regulation Of Phosphorylation Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Glycosylation Histone Deacetylase Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Circadian Rhythm Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Mitotic Spindle	Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Activity Regulation Of Primary Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Chromatin Remodeling Protein Lysine Deacetylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Nucleus Nucleoplasm Positive Regulation Of Developmental Process Negative Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Motility Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Protein-containing Complex
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