SUDS3

Description		SIN3A corepressor complex component SDS3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Sin3-type Complex
	Molecular Function	Histone Deacetylase Activity Protein Binding Enzyme Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Apoptotic Process Regulation Of Gene Expression Substantia Nigra Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance
Pathways		HDACs deacetylate histones NoRC negatively regulates rRNA expression Ub-specific processing proteases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal sclerosis ( 25188341) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)
Novel Interacting Genes		2 novel interacting genes: COL6A3 DYNLL1
Interacting Genes		7 interacting genes: BRMS1 CSNK2A1 GOLGA2 HDAC1 LDOC1 PTEN SRPK1
Entrez ID		64426
HPRD ID		12196
Ensembl ID		ENSG00000111707
Uniprot IDs		Q9H7L9
PDB IDs
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Cell Death Programmed Cell Death Apoptotic Process Meiotic Spindle Organization Meiotic Spindle Assembly Negative Regulation Of Stem Cell Population Maintenance NF-kappaB Binding Rhythmic Process Membraneless Organelle Assembly Organelle Assembly Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Motility Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Metabolic Process Spindle Assembly Enzyme Binding Krueppel-associated Box Domain Binding Negative Regulation Of Locomotion Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Collagen Type VI Trimer Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body PML Body Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Lysine Delactylase Activity Fungiform Papilla Formation Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Positive Regulation Of Protein Deacetylation Negative Regulation Of Phosphorylation Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Glycosylation Histone Deacetylase Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Circadian Rhythm Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Mitotic Spindle
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