POLR1E and KLC1

		POLR1E	KLC1
Description		RNA polymerase I subunit E	kinesin light chain 1
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Nucleolus RNA Polymerase I Complex	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection
	Molecular Function	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding Protein Binding	Cytoskeletal Motor Activity Protein Binding Kinesin Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Transcription Elongation By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: NFKBIB OGT POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF	29 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB
Entrez ID		64425	3831
HPRD ID		15096	02489
Ensembl ID		ENSG00000137054	ENSG00000126214
Uniprot IDs		B4E005 Q9GZS1	F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43	3NF1 5OJ8 7AI4 7AIE
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase I DNA-templated Transcription RNA Polymerase I Complex RRNA Transcription Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process DNA-directed RNA Polymerase Complex Transcription Initiation At RNA Polymerase I Promoter Fibrillar Center RNA Metabolic Process Nucleolus DNA-directed RNA Polymerase Activity Nucleic Acid Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity DNA/RNA Hybrid Binding 5'-3' RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process RRNA Metabolic Process DNA-templated Transcription Initiation RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase I Nucleoplasm Regulation Of Transcription By RNA Polymerase I Regulation Of Gluconeogenesis Chromosome Transcription Preinitiation Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleolus Organizer Region Negative Regulation Of Protein Ubiquitination Nucleus RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Localization To Nucleolus Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Protein Deglutarylation Protein-succinyllysine Desuccinylase Activity Protein Depropionylation Protein-glutaryllysine Deglutarylase Activity Nucleologenesis Negative Regulation Of Post-translational Protein Modification Nucleotidyltransferase Activity Regulation Of Glucose Metabolic Process Protein O-acetylglucosaminyltransferase Activity RNA Polymerase I Transcription Regulator Complex Ribonucleoside Binding Chromatin Binding Regulation Of Glucose Mediated Signaling Pathway	Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade
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