POLR1E and TAF1C

Number of citations of the paper that reports this interaction (PubMedID 15226435)
57

Data Source:
HPRD (in vitro)

		POLR1E	TAF1C
Description		RNA polymerase I subunit E	TATA-box binding protein associated factor, RNA polymerase I subunit C
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Nucleolus RNA Polymerase I Complex	Fibrillar Center Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus
	Molecular Function	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Transcription Elongation By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS			Autism ( 22843504) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		9 interacting genes: NFKBIB OGT POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF	14 interacting genes: H2AX POLR1E RRN3 SMN1 TAF1A TAF1B TBP TK1 TP53 TRIM24 TTR UBTF UFD1 VPS26C
Entrez ID		64425	9013
HPRD ID		15096	05364
Ensembl ID		ENSG00000137054	ENSG00000103168
Uniprot IDs		B4E005 Q9GZS1	B3KUE8 Q15572
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase I DNA-templated Transcription RNA Polymerase I Complex RRNA Transcription Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process DNA-directed RNA Polymerase Complex Transcription Initiation At RNA Polymerase I Promoter Fibrillar Center RNA Metabolic Process Nucleolus DNA-directed RNA Polymerase Activity Nucleic Acid Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity DNA/RNA Hybrid Binding 5'-3' RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process RRNA Metabolic Process DNA-templated Transcription Initiation RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase I Nucleoplasm Regulation Of Transcription By RNA Polymerase I Regulation Of Gluconeogenesis Chromosome Transcription Preinitiation Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleolus Organizer Region Negative Regulation Of Protein Ubiquitination Nucleus RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Localization To Nucleolus Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Protein Deglutarylation Protein-succinyllysine Desuccinylase Activity Protein Depropionylation Protein-glutaryllysine Deglutarylase Activity Nucleologenesis Negative Regulation Of Post-translational Protein Modification Nucleotidyltransferase Activity Regulation Of Glucose Metabolic Process Protein O-acetylglucosaminyltransferase Activity RNA Polymerase I Transcription Regulator Complex Ribonucleoside Binding Chromatin Binding Regulation Of Glucose Mediated Signaling Pathway	RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase I Transcription Preinitiation Complex Assembly Protein-DNA Complex Assembly RNA Polymerase Transcription Factor SL1 Complex Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Protein-containing Complex Assembly RNA Metabolic Process Protein-containing Complex Organization DNA-templated Transcription Initiation RRNA Transcription RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I RNA Polymerase I General Transcription Initiation Factor Activity Male Germ Cell Nucleus Macromolecule Metabolic Process Nucleoplasm Cellular Component Assembly Nucleus Regulation Of DNA-templated Transcription Initiation Nucleolus DNA Binding Core Promoter Sequence-specific DNA Binding Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Fibroblast Proliferation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Histone H3K23ac Reader Activity RNA Polymerase I Core Factor Complex RNA Polymerase I General Transcription Initiation Factor Binding RRNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Euchromatin MRNA Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Thymidine Kinase Activity Oligodendrocyte Apoptotic Process P53 Binding Negative Regulation Of Pentose-phosphate Shunt
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