POLR1E and SIRT7

Number of citations of the paper that reports this interaction (PubMedID 24207024)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		POLR1E	SIRT7
Description		RNA polymerase I subunit E	sirtuin 7
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Nucleolus RNA Polymerase I Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Nucleolus Organizer Region Cytoplasm Nuclear Speck Site Of Double-strand Break
	Molecular Function	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding Protein Binding	Chromatin Binding Protein Binding Protein Methyltransferase Activity Transferase Activity Hydrolase Activity NAD-dependent Protein Lysine Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Transcription Elongation By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Protein Deacetylation DNA Damage Response Homologous Chromosome Pairing At Meiosis RRNA Transcription Transposable Element Silencing Regulation Of Mitochondrion Organization Negative Regulation Of Protein Ubiquitination Epigenetic Regulation Of Gene Expression Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Gluconeogenesis Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Protein Export From Nucleus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Deglutarylation R-loop Processing Protein Depropionylation DNA Repair-dependent Chromatin Remodeling Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of RRNA Processing
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: NFKBIB OGT POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF	14 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 KAT2B MAGED1 NPM1 POLR1E PPARG RRP9 USP17L2 USP39 WDR77
Entrez ID		64425	51547
HPRD ID		15096	12094
Ensembl ID		ENSG00000137054	ENSG00000187531
Uniprot IDs		B4E005 Q9GZS1	Q9NRC8
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43	5IQZ 6G0S 9GMK 9GMR
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase I DNA-templated Transcription RNA Polymerase I Complex RRNA Transcription Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process DNA-directed RNA Polymerase Complex Transcription Initiation At RNA Polymerase I Promoter Fibrillar Center RNA Metabolic Process Nucleolus DNA-directed RNA Polymerase Activity Nucleic Acid Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity DNA/RNA Hybrid Binding 5'-3' RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process RRNA Metabolic Process DNA-templated Transcription Initiation RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase I Nucleoplasm Regulation Of Transcription By RNA Polymerase I Regulation Of Gluconeogenesis Chromosome Transcription Preinitiation Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleolus Organizer Region Negative Regulation Of Protein Ubiquitination Nucleus RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Localization To Nucleolus Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Protein Deglutarylation Protein-succinyllysine Desuccinylase Activity Protein Depropionylation Protein-glutaryllysine Deglutarylase Activity Nucleologenesis Negative Regulation Of Post-translational Protein Modification Nucleotidyltransferase Activity Regulation Of Glucose Metabolic Process Protein O-acetylglucosaminyltransferase Activity RNA Polymerase I Transcription Regulator Complex Ribonucleoside Binding Chromatin Binding Regulation Of Glucose Mediated Signaling Pathway	Chromatin Remodeling Protein-DNA Complex Assembly Structural Constituent Of Chromatin Nucleus Chromatin Organization Protein-containing Complex Assembly Nucleosome Assembly Nucleosome Nucleosome Organization Protein-containing Complex Organization Protein Heterodimerization Activity Negative Regulation Of Cell Population Proliferation Protein-containing Complex Negative Regulation Of Centrosome Duplication Epigenetic Regulation Of Gene Expression Transcription Coactivator Activity Negative Regulation Of Gene Expression Regulation Of Cell Population Proliferation Positive Regulation Of Glycolytic Process Nucleoplasm Regulation Of Centriole Replication Negative Regulation Of MiRNA Transcription Cellular Component Assembly Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Protein Localization To Nucleus Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of RNA Splicing DNA-binding Transcription Factor Binding Positive Regulation Of Fatty Acid Metabolic Process Chromatin Binding Regulation Of Protein Localization Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium DNA Binding Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Centrosome Duplication RNA Polymerase I General Transcription Initiation Factor Binding Oocyte Axis Specification Macromolecule Metabolic Process
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