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POLR1E and NFKBIB
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical)
HPRD
(in vitro)
POLR1E
NFKBIB
Description
RNA polymerase I subunit E
NFKB inhibitor beta
Image
GO Annotations
Cellular Component
DNA-directed RNA Polymerase Complex
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
RNA Polymerase I Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
RNA Polymerase I General Transcription Initiation Factor Binding
DNA Binding
Protein Binding
Transcription Coactivator Activity
Protein Binding
Biological Process
RNA Polymerase I Preinitiation Complex Assembly
DNA-templated Transcription
Transcription Initiation At RNA Polymerase I Promoter
Transcription Elongation By RNA Polymerase I
Nucleolar Large RRNA Transcription By RNA Polymerase I
DNA-templated Transcription
Inflammatory Response
Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of DNA-templated Transcription
Cellular Response To Lipopolysaccharide
Pathways
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
TAK1-dependent IKK and NF-kappa-B activation
TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Interacting Genes
9 interacting genes:
NFKBIB
OGT
POLR1A
POLR1B
POLR1C
POLR1G
SIRT7
TAF1C
UBTF
43 interacting genes:
APP
BAK1
BTBD6
BTRC
CDC25A
CHUK
CSNK2A1
CUL1
DNAJA3
ESR2
FHL3
GIT2
IKBKB
IKBKG
KPNA2
LRPPRC
MCC
MTIF2
NCOR2
NDUFB7
NFKB1
NFKB2
NFKBIA
NGFR
NKIRAS1
NKIRAS2
PDCD2
POLR1A
POLR1B
POLR1C
POLR1D
POLR1E
POLR1G
POLR2H
POLR2L
PPARG
RASAL2
REL
RELA
RXRA
SKP1
TSPAN1
VPS52
Entrez ID
64425
4793
HPRD ID
15096
07260
Ensembl ID
ENSG00000137054
ENSG00000104825
Uniprot IDs
B4E005
Q9GZS1
G5E9C2
Q15653
PDB IDs
7OB9
7OBA
7OBB
7VBA
7VBB
7VBC
8A43
9CK0
Enriched GO Terms of Interacting Partners
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Transcription By RNA Polymerase I
DNA-templated Transcription
RNA Polymerase I Complex
RRNA Transcription
Nucleobase-containing Compound Biosynthetic Process
Macromolecule Biosynthetic Process
DNA-directed RNA Polymerase Complex
Transcription Initiation At RNA Polymerase I Promoter
Fibrillar Center
RNA Metabolic Process
Nucleolus
DNA-directed RNA Polymerase Activity
Nucleic Acid Metabolic Process
RNA Polymerase I General Transcription Initiation Factor Activity
DNA/RNA Hybrid Binding
5'-3' RNA Polymerase Activity
Nucleobase-containing Compound Metabolic Process
RRNA Metabolic Process
DNA-templated Transcription Initiation
RNA Polymerase I Core Promoter Sequence-specific DNA Binding
RNA Polymerase I Preinitiation Complex Assembly
Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase I
Nucleoplasm
Regulation Of Transcription By RNA Polymerase I
Regulation Of Gluconeogenesis
Chromosome
Transcription Preinitiation Complex Assembly
Protein N-acetylglucosaminyltransferase Complex
Negative Regulation Of Non-canonical Inflammasome Complex Assembly
Nucleolus Organizer Region
Negative Regulation Of Protein Ubiquitination
Nucleus
RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Protein Localization To Nucleolus
Histone H3K18 Deacetylase Activity, NAD-dependent
NAD-dependent Protein-lysine Depropionylase Activity
Protein Deglutarylation
Protein-succinyllysine Desuccinylase Activity
Protein Depropionylation
Protein-glutaryllysine Deglutarylase Activity
Nucleologenesis
Negative Regulation Of Post-translational Protein Modification
Nucleotidyltransferase Activity
Regulation Of Glucose Metabolic Process
Protein O-acetylglucosaminyltransferase Activity
RNA Polymerase I Transcription Regulator Complex
Ribonucleoside Binding
Chromatin Binding
Regulation Of Glucose Mediated Signaling Pathway
RNA Polymerase I Complex
Non-canonical NF-kappaB Signal Transduction
DNA-directed RNA Polymerase Complex
Canonical NF-kappaB Signal Transduction
Nucleoplasm
DNA-directed RNA Polymerase Activity
Intracellular Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Transcription By RNA Polymerase I
DNA-templated Transcription
Intracellular Signaling Cassette
Negative Regulation Of Canonical NF-kappaB Signal Transduction
I-kappaB/NF-kappaB Complex
Cytosol
Regulation Of Intracellular Signal Transduction
RNA Polymerase III Complex
Regulation Of MiRNA Metabolic Process
Negative Regulation Of Signal Transduction
Nucleobase-containing Compound Biosynthetic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
RRNA Transcription
Tumor Necrosis Factor-mediated Signaling Pathway
IkappaB Kinase Complex
Negative Regulation Of MiRNA Transcription
Regulation Of Signal Transduction
Nucleus
DNA Binding
Macromolecule Biosynthetic Process
Regulation Of MiRNA Transcription
Transferrin Receptor Binding
Signal Transduction Involved In Regulation Of Gene Expression
Immune Response-activating Cell Surface Receptor Signaling Pathway
RNA Metabolic Process
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of DNA-binding Transcription Factor Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
NF-kappaB P50/p65 Complex
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Response To Cytokine
Response To Peptide
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Tumor Necrosis Factor
Positive Regulation Of T Cell Receptor Signaling Pathway
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