GREM2 and BMP4

Number of citations of the paper that reports this interaction (PMID 15039429)
17

Data Source:
HPRD (in vivo)

		GREM2	BMP4
Gene Name		gremlin 2, DAN family BMP antagonist	bone morphogenetic protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Cytokine Activity Heparin Binding BMP Binding Protein Homodimerization Activity	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity BMP Receptor Binding
	Biological Process	Embryonic Body Morphogenesis Cytokine-mediated Signaling Pathway BMP Signaling Pathway Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Regulation Of Cytokine Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKK Activity Osteoblast Differentiation Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Renal System Process BMP Signaling Pathway Involved In Heart Induction Secondary Heart Field Specification Endocardial Cushion Development Cardiac Septum Development Type B Pancreatic Cell Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Germ Cell Development Mesodermal Cell Fate Determination Negative Regulation Of Cell Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Organ Position Regulation Of Cell Fate Commitment Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cell Death Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Extracellular Matrix Organization Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Regulation Of Protein Import Into Nucleus Negative Regulation Of Phosphorylation Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Intermediate Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Smooth Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Inner Ear Receptor Cell Differentiation Cloacal Septation Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Lung Morphogenesis Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Negative Regulation Of Cell Death Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis BMP Signaling Pathway Involved In Ureter Morphogenesis BMP Signaling Pathway Involved In Renal System Segmentation Pulmonary Artery Endothelial Tube Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus BMP Signaling Pathway Involved In Nephric Duct Formation Renal System Development Glomerular Visceral Epithelial Cell Development Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesenchymal Cell Differentiation Involved In Kidney Development Ureter Epithelial Cell Differentiation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Metanephric Collecting Duct Development Positive Regulation Of Kidney Development Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of DNA-dependent DNA Replication Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Signaling by BMP	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Ankle-brachial index ( 22199011) Immune response to smallpox vaccine (IL-6) ( 22542470)	Colorectal cancer ( 19011631) Dental caries ( 23259602) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease ( 19915575) Primary tooth development (time to first tooth eruption) ( 23704328)
Protein-Protein Interactions		2 interactors: BMP2 BMP4	15 interactors: BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 GREM2 HTRA1 NOG SOSTDC1 STAP2 TWSG1 ZFYVE9
Entrez ID		64388	652
HPRD ID		16390	00207
Ensembl ID		ENSG00000180875	ENSG00000125378
Uniprot IDs		Q9H772	P12644 Q53XC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Mesenchymal Cell Proliferation Involved In Ureteric Bud Development BMP Signaling Pathway Involved In Heart Induction BMP Signaling Pathway Involved In Heart Development Telencephalon Regionalization Cell Proliferation Involved In Kidney Development Regulation Of Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Proliferation Regulation Of Transcription Involved In Cell Fate Commitment Forebrain Regionalization Regulation Of Odontogenesis Regulation Of Heart Morphogenesis Organ Induction Endocardial Cushion Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Muscle Cell Differentiation Glandular Epithelial Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Developmental Induction Regulation Of Organ Formation Negative Regulation Of Muscle Organ Development Pituitary Gland Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Endothelial Cell Proliferation Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Nephron Morphogenesis Chondrocyte Differentiation Renal Tubule Morphogenesis Regulation Of Endothelial Cell Proliferation Stem Cell Proliferation Regulation Of Cartilage Development Diencephalon Development Positive Regulation Of Ossification Renal Tubule Development Regulation Of Striated Muscle Cell Differentiation Kidney Morphogenesis Odontogenesis Of Dentin-containing Tooth Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of ERK1 And ERK2 Cascade Mesonephros Development	Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cartilage Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Connective Tissue Development Regulation Of Osteoblast Differentiation Organ Development Regulation Of Ossification Tissue Development Pattern Specification Process Mesoderm Formation Mesoderm Morphogenesis Multicellular Organismal Development Negative Regulation Of Chondrocyte Proliferation Anatomical Structure Development Skeletal System Development Ossification Sensory Organ Development Organ Morphogenesis Dorsal/ventral Pattern Formation Formation Of Primary Germ Layer Regulation Of Cytokine Activity Cell Surface Receptor Signaling Pathway System Development Mesoderm Development Developmental Process Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation Proteoglycan Biosynthetic Process Limb Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Regulation Of Epithelial Cell Proliferation Embryonic Morphogenesis Tissue Morphogenesis Cell Differentiation
Tagcloud ?		additive aldosterone c14 cerebrus dan deubiquitylates deubiquitylating distal enac glucocorticoid hek293 interferes microselected mineralocorticoid modulator mpkccd nephron oocytes prdc reabsorption sgk1 sodium stimulatory tubule tubules ubiquitylation usp2 verified xenopus	agonists antagonists apoptosis bmp2 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety
Tagcloud (Difference) ?		additive aldosterone c14 cerebrus dan deubiquitylates deubiquitylating distal enac glucocorticoid hek293 interferes microselected mineralocorticoid modulator mpkccd nephron oocytes prdc reabsorption sgk1 sodium stimulatory tubule tubules ubiquitylation usp2 verified xenopus	agonists antagonists apoptosis bmp2 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety
Tagcloud (Intersection) ?