GREM2 and QSOX1

		GREM2	QSOX1
Description		gremlin 2, DAN family BMP antagonist	quiescin sulfhydryl oxidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Platelet Alpha Granule Lumen Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Cytokine Activity Heparin Binding BMP Binding Identical Protein Binding Receptor Ligand Activity	Protein Disulfide Isomerase Activity Oxidoreductase Activity Flavin-dependent Sulfhydryl Oxidase Activity Thiol Oxidase Activity FAD Binding
	Biological Process	Embryonic Body Morphogenesis Cytokine-mediated Signaling Pathway Negative Regulation Of BMP Signaling Pathway Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Regulation Of Cytokine Activity	Protein Folding Negative Regulation Of Macroautophagy Extracellular Matrix Assembly
Pathways		Signaling by BMP	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Ankle-brachial index ( 22199011) Heel bone mineral density ( 31453325) Heel bone mineral density variance ( 31453325) Immune response to smallpox vaccine (IL-6) ( 22542470) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 32888494) Response to allopurinol in gout (change in serum uric acid levels) ( 30924126)	Anorexia nervosa ( 23568457) Pulse pressure ( 30224653 30578418)
Interacting Genes		2 interacting genes: BMP2 BMP4	7 interacting genes: BEGAIN CCR1 CCR6 CHRM4 SHANK3 UBE2D2 UBQLN4
Entrez ID		64388	5768
HPRD ID		16390	06785
Ensembl ID		ENSG00000180875	ENSG00000116260
Uniprot IDs		Q9H772	A0A140VKE5 O00391
PDB IDs			3LLI 3LLK 3Q6O 4IJ3
Enriched GO Terms of Interacting Partners?		Cardiac Jelly Development Heart Induction Ameloblast Differentiation Telencephalon Regionalization Positive Regulation Of Odontoblast Differentiation Positive Regulation Of Neuroepithelial Cell Differentiation Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Heart Morphogenesis Regulation Of Odontoblast Differentiation Co-receptor Binding Lung Vasculature Development BMP Receptor Binding Regulation Of Odontogenesis Regulation Of Cardiac Muscle Cell Differentiation Organ Induction Developmental Induction Regulation Of Animal Organ Formation Cellular Response To BMP Stimulus Positive Regulation Of P38MAPK Cascade Telencephalon Development Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cartilage Development Cardiac Muscle Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of P38MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Cardiocyte Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Heart Valve Morphogenesis Heart Morphogenesis Vasculature Development Negative Regulation Of Smooth Muscle Cell Proliferation Mesenchyme Development Chondrocyte Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial Cell Differentiation Regulation Of SMAD Protein Signal Transduction Regulation Of Cartilage Development Striated Muscle Cell Differentiation Positive Regulation Of Osteoblast Differentiation Bone Development Odontogenesis Of Dentin-containing Tooth Protein Serine/threonine Kinase Activator Activity Muscle Tissue Morphogenesis Regulation Of MiRNA Transcription Regulation Of Bone Mineralization Regulation Of Animal Organ Morphogenesis BMP Signaling Pathway	G Protein-coupled Receptor Activity Chemokine Receptor Activity Dendritic Cell Migration Dendritic Cell Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Synaptic Transmission Regulation Of Neuron Projection Regeneration Positive Regulation Of Synaptic Transmission, Glutamatergic
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