GREM2 and BMP2

Number of citations of the paper that reports this interaction (PMID 15039429)
17

Data Source:
HPRD (in vivo)

		GREM2	BMP2
Gene Name		gremlin 2, DAN family BMP antagonist	bone morphogenetic protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	Cytokine Activity Heparin Binding BMP Binding Protein Homodimerization Activity	Retinol Dehydrogenase Activity Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Phosphatase Activator Activity SMAD Binding Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Embryonic Body Morphogenesis Cytokine-mediated Signaling Pathway BMP Signaling Pathway Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Regulation Of Cytokine Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Skeletal System Development Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation BMP Signaling Pathway Involved In Heart Induction Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Proteoglycan Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Negative Regulation Of Cell Proliferation Embryo Development Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Protein Destabilization Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Bone Mineralization Involved In Bone Maturation Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Mesenchyme Development Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Positive Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Signaling by BMP	Molecules associated with elastic fibres Elastic fibre formation Signaling by BMP
Drugs
Diseases
GWAS		Ankle-brachial index ( 22199011) Immune response to smallpox vaccine (IL-6) ( 22542470)	Body mass index ( 19079261 23669352) Colorectal cancer ( 23266556) Height ( 20881960 23563607 18391951) Obesity-related traits ( 23251661) Refractive error ( 23396134) Sagittal craniosynostosis ( 23160099)
Protein-Protein Interactions		2 interactors: BMP2 BMP4	19 interactors: ACTR2 ACVR1 ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG SOSTDC1 TGFB1 TGFB2
Entrez ID		64388	650
HPRD ID		16390	00206
Ensembl ID		ENSG00000180875	ENSG00000125845
Uniprot IDs		Q9H772	C8C060 P12643
PDB IDs			1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP
Enriched GO Terms of Interacting Partners?		Mesenchymal Cell Proliferation Involved In Ureteric Bud Development BMP Signaling Pathway Involved In Heart Induction BMP Signaling Pathway Involved In Heart Development Telencephalon Regionalization Cell Proliferation Involved In Kidney Development Regulation Of Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Proliferation Regulation Of Transcription Involved In Cell Fate Commitment Forebrain Regionalization Regulation Of Odontogenesis Regulation Of Heart Morphogenesis Organ Induction Endocardial Cushion Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Muscle Cell Differentiation Glandular Epithelial Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Developmental Induction Regulation Of Organ Formation Negative Regulation Of Muscle Organ Development Pituitary Gland Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Endothelial Cell Proliferation Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Nephron Morphogenesis Chondrocyte Differentiation Renal Tubule Morphogenesis Regulation Of Endothelial Cell Proliferation Stem Cell Proliferation Regulation Of Cartilage Development Diencephalon Development Positive Regulation Of Ossification Renal Tubule Development Regulation Of Striated Muscle Cell Differentiation Kidney Morphogenesis Odontogenesis Of Dentin-containing Tooth Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of ERK1 And ERK2 Cascade Mesonephros Development	Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification BMP Signaling Pathway Regulation Of BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Development Pattern Specification Process Tube Development Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Skeletal System Development Epithelium Development Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cartilage Development Regulation Of Signal Transduction Organ Morphogenesis Multicellular Organismal Development Organ Development Connective Tissue Development Anatomical Structure Development Regulation Of Signaling System Development Positive Regulation Of Bone Mineralization Cell Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Developmental Process Dorsal/ventral Pattern Formation Regulation Of Osteoblast Differentiation Embryonic Morphogenesis Tissue Morphogenesis Skeletal System Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cartilage Development Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Embryo Development Negative Regulation Of Signaling Regulation Of Cell Differentiation Sensory Organ Development Positive Regulation Of Signal Transduction Mesoderm Development Cell Development Signal Transduction By Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Stem Cell Differentiation
Tagcloud ?		additive aldosterone c14 cerebrus dan deubiquitylates deubiquitylating distal enac glucocorticoid hek293 interferes microselected mineralocorticoid modulator mpkccd nephron oocytes prdc reabsorption sgk1 sodium stimulatory tubule tubules ubiquitylation usp2 verified xenopus	agonists antagonists apoptosis bmp4 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety
Tagcloud (Difference) ?		additive aldosterone c14 cerebrus dan deubiquitylates deubiquitylating distal enac glucocorticoid hek293 interferes microselected mineralocorticoid modulator mpkccd nephron oocytes prdc reabsorption sgk1 sodium stimulatory tubule tubules ubiquitylation usp2 verified xenopus	agonists antagonists apoptosis bmp4 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety
Tagcloud (Intersection) ?