GREM2

Gene Name		gremlin 2, DAN family BMP antagonist
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Heparin Binding BMP Binding Protein Homodimerization Activity
	Biological Process	Embryonic Body Morphogenesis Cytokine-mediated Signaling Pathway BMP Signaling Pathway Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Regulation Of Cytokine Activity
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Ankle-brachial index ( 22199011) Immune response to smallpox vaccine (IL-6) ( 22542470)
Protein-protein Interactions		2 interactors: BMP2 BMP4
Entrez ID		64388
HPRD ID		16390
Ensembl ID		ENSG00000180875
Uniprot IDs		Q9H772
PDB IDs
Enriched GO Terms of Interacting Partners?		Mesenchymal Cell Proliferation Involved In Ureteric Bud Development BMP Signaling Pathway Involved In Heart Induction BMP Signaling Pathway Involved In Heart Development Telencephalon Regionalization Cell Proliferation Involved In Kidney Development Regulation Of Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Proliferation Regulation Of Transcription Involved In Cell Fate Commitment Forebrain Regionalization Regulation Of Odontogenesis Regulation Of Heart Morphogenesis Organ Induction Endocardial Cushion Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Muscle Cell Differentiation Glandular Epithelial Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Developmental Induction Regulation Of Organ Formation Negative Regulation Of Muscle Organ Development Pituitary Gland Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Endothelial Cell Proliferation Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Nephron Morphogenesis Chondrocyte Differentiation Renal Tubule Morphogenesis Regulation Of Endothelial Cell Proliferation Stem Cell Proliferation Regulation Of Cartilage Development Diencephalon Development Positive Regulation Of Ossification Renal Tubule Development Regulation Of Striated Muscle Cell Differentiation Kidney Morphogenesis Odontogenesis Of Dentin-containing Tooth Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of ERK1 And ERK2 Cascade Mesonephros Development
Tagcloud ?		additive aldosterone c14 cerebrus dan deubiquitylates deubiquitylating distal enac glucocorticoid hek293 interferes microselected mineralocorticoid modulator mpkccd nephron oocytes prdc reabsorption sgk1 sodium stimulatory tubule tubules ubiquitylation usp2 verified xenopus