GREM2

Description		gremlin 2, DAN family BMP antagonist
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Heparin Binding BMP Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Embryonic Body Morphogenesis Cytokine-mediated Signaling Pathway Negative Regulation Of BMP Signaling Pathway Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Regulation Of Cytokine Activity
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Ankle-brachial index ( 22199011) Heel bone mineral density ( 31453325) Heel bone mineral density variance ( 31453325) Immune response to smallpox vaccine (IL-6) ( 22542470) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 32888494) Response to allopurinol in gout (change in serum uric acid levels) ( 30924126)
Novel Interacting Genes		1 novel interacting genes: QSOX1
Interacting Genes		2 interacting genes: BMP2 BMP4
Entrez ID		64388
HPRD ID		16390
Ensembl ID		ENSG00000180875
Uniprot IDs		Q9H772
PDB IDs
Enriched GO Terms of Interacting Partners?		Cardiac Jelly Development Heart Induction Ameloblast Differentiation Telencephalon Regionalization Positive Regulation Of Odontoblast Differentiation Positive Regulation Of Neuroepithelial Cell Differentiation Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Heart Morphogenesis Regulation Of Odontoblast Differentiation Co-receptor Binding Lung Vasculature Development BMP Receptor Binding Regulation Of Odontogenesis Regulation Of Cardiac Muscle Cell Differentiation Organ Induction Developmental Induction Regulation Of Animal Organ Formation Cellular Response To BMP Stimulus Positive Regulation Of P38MAPK Cascade Telencephalon Development Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cartilage Development Cardiac Muscle Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of P38MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Cardiocyte Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Heart Valve Morphogenesis Heart Morphogenesis Vasculature Development Negative Regulation Of Smooth Muscle Cell Proliferation Mesenchyme Development Chondrocyte Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial Cell Differentiation Regulation Of SMAD Protein Signal Transduction Regulation Of Cartilage Development Striated Muscle Cell Differentiation Positive Regulation Of Osteoblast Differentiation Bone Development Odontogenesis Of Dentin-containing Tooth Protein Serine/threonine Kinase Activator Activity Muscle Tissue Morphogenesis Regulation Of MiRNA Transcription Regulation Of Bone Mineralization Regulation Of Animal Organ Morphogenesis BMP Signaling Pathway
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