PTPN1 and ESR1

Number of citations of the paper that reports this interaction (PubMedID 7539106)
0

Data Source:
HPRD (in vitro)

		PTPN1	ESR1
Description		protein tyrosine phosphatase non-receptor type 1	estrogen receptor 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Mitochondrial Crista Endosome Lumen Protein-containing Complex Sorting Endosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane Postsynapse Glutamatergic Synapse	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Protein-containing Complex
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Enzyme Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Cadherin Binding Ephrin Receptor Binding Protein Phosphatase 2A Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Calmodulin Binding Beta-catenin Binding Zinc Ion Binding Lipid Binding TBP-class Protein Binding Enzyme Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Nuclear Estrogen Receptor Activity Nuclear Estrogen Receptor Binding Estrogen Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding ATPase Binding 14-3-3 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Systemic Arterial Blood Pressure Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Heart Rate Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Actin Cytoskeleton Organization Regulation Of Endocytosis Regulation Of Proteolysis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Cellular Response To Insulin Stimulus Regulation Of Intracellular Protein Transport Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Peptidyl-tyrosine Dephosphorylation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus IRE1-mediated Unfolded Protein Response Insulin Receptor Recycling Negative Regulation Of MAP Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of JNK Cascade Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Hypoxia Cellular Response To Nitric Oxide Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Regulation Of Postsynapse Assembly Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Cellular Response To Nerve Growth Factor Stimulus Response To Angiotensin Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Receptor Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Antral Ovarian Follicle Growth Epithelial Cell Development Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Androgen Metabolic Process Male Gonad Development Negative Regulation Of Gene Expression Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Estrogen Receptor Signaling Pathway Response To Estradiol Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Steroid Hormone Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Response To Estrogen Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Stem Cell Differentiation Regulation Of Inflammatory Response Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Preinitiation Complex Assembly Uterus Development Vagina Development Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Protein Localization To Chromatin Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen-containing Compound Negative Regulation Of MiRNA Transcription Regulation Of Epithelial Cell Apoptotic Process
Pathways		Integrin signaling Negative regulation of MET activity Insulin receptor recycling Regulation of IFNG signaling PTK6 Down-Regulation MECP2 regulates neuronal receptors and channels Regulation of IFNA/IFNB signaling Growth hormone receptor signaling Growth hormone receptor signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Nuclear signaling by ERBB4 PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors RUNX1 regulates estrogen receptor mediated transcription ESR-mediated signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Extra-nuclear estrogen signaling Estrogen-dependent gene expression Mitochondrial unfolded protein response (UPRmt) Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid 2-{[4-(2-Acetylamino-2-pentylcarbamoyl-ethyl)-naphthalen-1-YL]-oxalyl-amino}-benzoic acid 5-(2-Fluoro-5-{(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]-1-propen-1-yl}phenyl)-1,2-oxazole-3-carboxylic acid 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid, {4-[(2S)-2-({[(1S)-1-Carboxy-2-phenylethyl]carbamoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonic acid Compound 19 3-(4-{2-[2-(2-bromo-acetylamino)-ethyldisulfanyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-pyrazine-2-carboxylic acid 2-(Oxalyl-Amino)-Benzoic Acid {[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid) Novo Nordisk a/S Compound N-(Bromoacetyl)-beta-alanyl-N-(2-{4-[(carboxycarbonyl)amino]phenyl}ethyl)-L-serinamide 7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid PNU177836 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide (4S)-5-[[(2S)-1-[[(2S)-1-Amino-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acid 4-[[(2S)-1-[[6-[(1-Amino-1-oxo-3-sulfanylpropan-2-yl)amino]-6-oxohexyl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[[2-[4-[difluoro(phosphono)methyl]phenyl]acetyl]amino]-4-oxobutanoic acid L-cysteic acid 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid -Carbonyl]-Amino}-Butyric Acid Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid 2-[{4-[(2S)-2-{[(Allyloxy)carbonyl]amino}-3-({4-[3-hydroxy-2-(methoxycarbonyl)phenoxy]butyl}amino)-3-oxopropyl]phenyl}(carboxycarbonyl)amino]benzoic acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid {4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid N-(3-Carboxypropanoyl)-L-phenylalanyl-3-carboxy-O-(carboxymethyl)-N-pentyl-L-tyrosinamide 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID ISIS 113715 Trodusquemine Ertiprotafib 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID [(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE [(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID ISOTHIAZOLIDINONE ANALOG 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid p-Benzoyl-L-phenylalanine 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid	Diethylstilbestrol Chlorotrianisene Conjugated estrogens Desogestrel Levonorgestrel Progesterone Lindane Raloxifene Toremifene Medroxyprogesterone acetate Testosterone Mitotane Estrone Tamoxifen Hexachlorophene Estradiol Ethynodiol diacetate Dobutamine Clomifene Dienestrol Fulvestrant Norgestimate Ethinylestradiol Melatonin Trilostane Naloxone Fluoxymesterone Estramustine Mestranol Danazol Oxybenzone Allylestrenol Zinc Genistein Prasterone Benzophenone Equilin Compound 19 Resveratrol Compound 18 Phthalic Acid Pyrazole Stanolone Naringenin Compound 4-D 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol Quercetin Afimoxifene 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol Estriol Estrone sulfate Quinestrol Phenolphthalein Permethrin Ospemifene AP1081 Custirsen NP-50301 CHF 4227 TAS-108 Lasofoxifene Arzoxifene Elacestrant Bazedoxifene Methyltestosterone beta-Naphthoflavone 17-METHYL-17-ALPHA-DIHYDROEQUILENIN din-6-yl)phenol [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL Hexestrol dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate Erteberel N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol Tibolone Eugenol Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, B Polyestradiol phosphate Norethynodrel Octocrylene Homosalate Enzacamene Zeranol Ractopamine Gestrinone Estetrol Propyl Gallate Ormeloxifene 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol Testosterone cypionate Testosterone enanthate Stanolone acetate Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate Fluoroestradiol F-18
Diseases
GWAS		Appendicular lean mass ( 33097823) Basophil count ( 32888494) Colorectal cancer ( 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Intraocular pressure ( 29617998 29785010 30054594 31959993) Lymphocyte percentage of white cells ( 32888494) Thyroid stimulating hormone levels ( 30843173) Vitiligo ( 27723757)	Age at first birth ( 27089180 34211149 27798627) Age at first sexual intercourse ( 27089180 34211149) Alcohol dependence ( 19581569) Anxiety ( 31906708) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone mineral density ( 23437003) Bone mineral density (hip) ( 18445777 19801982 19079262) Bone mineral density (spine) ( 30172743 27424934 18445777 26911590 19079262 19801982) Bone mineral density (Ward's triangle area) ( 27397699) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 21263130 22383897 29059683 25327703 31757997 27117709 23535729 23535733 20453838 19219042) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Breast size ( 29855537 27182965 22747683) Chronic myeloid leukemia ( 21540461) Developmental language disorder ( 27016271) Diastolic blood pressure ( 30578418) Endometriosis ( 28537267) Fractures ( 30158200) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 31453325 28869591 30598549 30048462) Heel bone mineral density variance ( 31453325) Height ( 25282103 33713608 28552196 31562340 20881960 23563607) Hip circumference adjusted for BMI ( 34021172) Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Mammographic density (dense area) ( 25342443) Menarche (age at onset) ( 25231870) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 28135244 30578418 27841878) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (dichotomous) ( 28628665) Smoking status (current vs former) ( 27393504) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 30578418 27841878) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Western dietary pattern ( 28644415)
Interacting Genes		68 interacting genes: ABL1 ACTN1 AGR3 AKT1 AQP6 ASS1 BCAR1 BCAS3 BCR CAPN2 CASC3 CASZ1 CAV1 CCL5 CDH13 CDH2 CDK1 CLK1 CLK2 COP1 CRK CSNK2A1 CSNK2A2 CTNNB1 DIRAS3 EGFR ELOVL4 ESR1 FGFR1 GHR GLRX GRB2 GSK3B IGF1R INSR IRS1 JAK2 KLK7 LAT LRATD2 LTK MAPK1 MRC2 NFKBIA NTRK1 NTRK2 NTRK3 PDGFRB PIAS1 PIGP PIN1 PRKCA RHOBTB2 RRAS2 SNAI1 SRC STAM2 STAT3 STAT5A STAT5B THRSP TIMMDC1 TMEM31 TMEM41A TMEM86B TRPV6 TYK2 VPS45	370 interacting genes: ACTN4 AHR AKAP13 AKT1 AKT2 ALYREF ANGPTL4 ANP32B AR ARHGEF15 ARID1A ARNT ATAD2 BAG1 BAP1 BARD1 BCAR1 BCAS2 BDNF BRCA1 CALM1 CALM2 CALM3 CAV1 CBLL1 CCND1 CCNH CCNT1 CCT2 CDC25B CDK2 CDK7 CDK8 CDKN1A CEBPA CEBPB CFL1 CHD9 CHUK CITED1 COPS5 CREBBP CSNK2B CSRP1 CTNNB1 CUEDC2 CUL4B CXCL1 DAP3 DARS1 DBN1 DDX1 DDX17 DDX3X DDX5 DDX54 DNMT3L DNTTIP2 DUT EEF2 EGFR EHMT2 EIF2S2 EIF3I EIF4A3 EP300 EPAS1 EPSTI1 ERBB2 ESR2 ESRRA FARSA FBH1 FHL2 FKBP4 FKBP5 FLII FOXK2 FOXO1 FOXO3 FOXO4 FUBP1 GADD45B GADD45G GLCE GNAI1 GRB2 GREB1 GRIP1 GRWD1 GTF2B GTF2H1 H2AC20 H2BC10 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H3-3A H3-3B HBP1 HDAC3 HDAC4 HDAC5 HDAC9 HDLBP HEXIM1 HNF4A HNRNPA1 HNRNPA2B1 HNRNPC HNRNPD HSP90AA1 HSP90AB1 HSP90B1 HSPA4 HSPA8 HSPB1 IGF1R ILF3 ING1 ISL1 ITGB3BP JUN JUNB JUND KARS1 KAT5 KDM5A KIF1A KLF5 KLK5 KLK9 KMT2D KMT5B KRT10 KRT18 KRT19 KRT8 LARS1 LCK LCOR LDB1 LINC00312 LRIF1 MAPK1 MAPK14 MAPK3 MARS1 MDM2 MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED27 MED6 MED7 MEN1 MGMT MINDY1 MKNK2 MMS19 MNAT1 MPG MSH2 MTA1 MTA2 MTCH2 MTHFD1 MTOR MUC1 MVP MYBBP1A MYH6 NAP1L4 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOA7 NCOR1 NCOR2 NELFB NFKB1 NONO NPM1 NPPA NR0B1 NR0B2 NR1H4 NR2C1 NR2C2 NR2F1 NR2F6 NRIP1 NSD1 NSD2 NSD3 NSF NUDT21 OTUB1 P4HB PA2G4 PAGR1 PAK1 PAK6 PBXIP1 PDIA3 PELP1 PGC PGR PHB1 PHB2 PIAS1 PIAS2 PIAS3 PIK3R1 PIK3R3 PNRC2 POLR1B POLR2A POLR2D POU2F1 POU2F2 POU4F1 POU4F2 PPARGC1A PPARGC1B PPIB PPID PPP1CA PPP2R1A PQBP1 PRDM2 PRKACA PRKCSH PRMT1 PRMT2 PRPF19 PRPF6 PSMC3IP PSMC5 PSMD1 PSPC1 PTEN PTGES3 PTMA PTPN1 PTPN6 RAC3 RACK1 RANBP9 RARA RBBP4 RBBP7 RBFOX2 RBM23 RBM39 RELA REXO4 RFX4 RGS3 RLIM RNF111 RNF14 RNF4 RPL9 RPS6KA1 RPS6KA3 RTCB RXRA SAFB SAFB2 SARNP SARS2 SEPTIN2 SEPTIN8 SERBP1 SERPINB5 SET SETD7 SFMBT2 SFPQ SHC1 SHMT2 SKIL SKP2 SLC30A9 SMAD2 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCD3 SMARCE1 SMC1A SMC3 SMYD2 SND1 SNX6 SOS1 SP1 SP3 SRA1 SRC SREBF1 STAT3 STAT5A STRN STUB1 SUV39H1 SVIL SYNCRIP TADA3 TAF10 TAF1A TAF1B TAF2 TAP1 TBP TCERG1 TCF20 TDG THRA THRB TNFRSF14 TOPBP1 TP53 TRAM1 TRIM24 TRIM25 TRIM28 TRIM59 TRIM8 TRIP4 TRRAP TSC2 TUBA1B TUBA1C TUBB TXNRD1 UBE2I UBE3A UBE4B UBR5 UIMC1 USF1 VAV3 VCP WBP2 WIPI1 XAF1 XBP1 YARS1 YWHAH YWHAQ ZBTB16 ZBTB17 ZNF398
Entrez ID		5770	2099
HPRD ID		01477	00589
Ensembl ID		ENSG00000196396	ENSG00000091831
Uniprot IDs		A8K3M3 B4DSN5 P18031	A0A125SXW3 A8KAF4 G4XH65 H0Y4W6 P03372 Q9UBT1
PDB IDs		1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1WAX 1XBO 2AZR 2B07 2B4S 2BGD 2BGE 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2CNE 2CNF 2CNG 2CNH 2CNI 2F6F 2F6T 2F6V 2F6W 2F6Y 2F6Z 2F70 2F71 2FJM 2FJN 2H4G 2H4K 2HB1 2HNP 2HNQ 2NT7 2NTA 2QBP 2QBQ 2QBR 2QBS 2VEU 2VEV 2VEW 2VEX 2VEY 2ZMM 2ZN7 3A5J 3A5K 3CWE 3D9C 3EAX 3EB1 3EU0 3I7Z 3I80 3QKP 3QKQ 3SME 3ZMP 3ZMQ 3ZV2 4BJO 4I8N 4QAH 4QAP 4QBE 4QBW 4Y14 4ZRT 5K9V 5K9W 5KA0 5KA1 5KA2 5KA3 5KA4 5KA7 5KA8 5KA9 5KAA 5KAB 5KAC 5KAD 5QDE 5QDF 5QDG 5QDH 5QDI 5QDJ 5QDK 5QDL 5QDM 5QDN 5QDO 5QDP 5QDQ 5QDR 5QDS 5QDT 5QDU 5QDV 5QDW 5QDX 5QDY 5QDZ 5QE0 5QE1 5QE2 5QE3 5QE4 5QE5 5QE6 5QE7 5QE8 5QE9 5QEA 5QEB 5QEC 5QED 5QEE 5QEF 5QEG 5QEH 5QEI 5QEJ 5QEK 5QEL 5QEM 5QEN 5QEO 5QEP 5QEQ 5QER 5QES 5QET 5QEU 5QEV 5QEW 5QEX 5QEY 5QEZ 5QF0 5QF1 5QF2 5QF3 5QF4 5QF5 5QF6 5QF7 5QF8 5QF9 5QFA 5QFB 5QFC 5QFD 5QFE 5QFF 5QFG 5QFH 5QFI 5QFJ 5QFK 5QFL 5QFM 5QFN 5QFO 5QFP 5QFQ 5QFR 5QFS 5QFT 5QFU 5QFV 5QFW 5QFX 5QFY 5QFZ 5QG0 5QG1 5QG2 5QG3 5QG4 5QG5 5QG6 5QG7 5QG8 5QG9 5QGA 5QGB 5QGC 5QGD 5QGE 5QGF 5T19 6B8E 6B8T 6B8X 6B8Z 6B90 6B95 6BAI 6CWU 6CWV 6NTP 6OL4 6OLQ 6OLV 6OMY 6PFW 6PG0 6PGT 6PHA 6PHS 6PM8 6W30 6XE8 6XEA 6XED 6XEE 6XEF 6XEG 7FQM 7FQN 7FQO 7FQP 7FQQ 7FQR 7FQS 7FQT 7FQU 7FQV 7FQW 7FQX 7FQY 7FQZ 7FRE 7FRF 7FRG 7FRH 7FRI 7FRJ 7FRK 7FRL 7FRM 7FRN 7FRO 7FRP 7FRQ 7FRR 7FRS 7FRT 7FRU 7GS7 7GS8 7GS9 7GSA 7GSB 7GSC 7GSD 7GSE 7GSF 7GSG 7GSH 7GSI 7GSJ 7GSK 7GSL 7GSM 7GSN 7GSO 7GSQ 7GSR 7GST 7GSU 7GSV 7GSW 7GSX 7GSY 7GSZ 7GT0 7GT1 7GT2 7GT3 7GT4 7GT5 7GT6 7GT7 7GT8 7GT9 7GTA 7GTB 7GTC 7GTD 7GTE 7GTF 7GTG 7GTH 7GTI 7GTJ 7GTK 7GTL 7GTM 7GTN 7GTO 7GTP 7GTQ 7GTR 7GTS 7GTT 7GTU 7GTV 7GTW 7GTX 7GTY 7GTZ 7GU0 7GU1 7GU2 7GU3 7GU4 7GU5 7GU6 7GU7 7GU8 7GU9 7GUA 7GUB 7GUC 7KEN 7KEY 7KLX 7L0C 7L0H 7LFO 7MKZ 7MM1 7MN7 7MN9 7MNA 7MNB 7MNC 7MND 7MNE 7MNF 7MOU 7MOV 7MOW 7RIN 7S4F 8DU7 8EXI 8EXJ 8EXK 8EXM 8EXN 8EYA 8EYB 8EYC 8F88 8G65 8G67 8G68 8G69 8G6A 8SKL 8U1E 8XOY 9C66 9CYO 9CYP 9CYQ 9CYR	1A52 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2B1Z 2B23 2BJ4 2FAI 2G44 2G5O 2I0J 2IOG 2IOK 2JF9 2JFA 2LLO 2LLQ 2OCF 2OUZ 2P15 2POG 2Q6J 2Q70 2QA6 2QA8 2QAB 2QE4 2QGT 2QGW 2QH6 2QR9 2QSE 2QXM 2QXS 2QZO 2R6W 2R6Y 2YAT 2YJA 3CBM 3CBO 3CBP 3DT3 3ERD 3ERT 3HLV 3HM1 3L03 3OS8 3OS9 3OSA 3Q95 3UU7 3UUA 3UUC 3UUD 4AA6 4DMA 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4JC3 4JDD 4MG5 4MG6 4MG7 4MG8 4MG9 4MGA 4MGB 4MGC 4MGD 4O6F 4PP6 4PPP 4PPS 4PXM 4Q13 4Q50 4TUZ 4TV1 4XI3 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 5AAU 5AAV 5ACC 5AK2 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EGV 5EHJ 5EI1 5EIT 5FQP 5FQR 5FQS 5FQT 5FQV 5GS4 5GTR 5HYR 5JMM 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5N10 5T0X 5T1Z 5T92 5T97 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5TN9 5TNB 5U2B 5U2D 5UFW 5UFX 5W9C 5W9D 5WGD 5WGQ 6B0F 6C42 6CBZ 6CHW 6CHZ 6CZN 6D0F 6DF6 6DFN 6HHP 6HKB 6HKF 6HMU 6IAR 6OWC 6PET 6PFM 6PIT 6PSJ 6SBO 6SQ0 6SUO 6TJM 6TL3 6V87 6V8T 6VGH 6VJD 6VPF 6WOK 6ZOQ 6ZOR 6ZOS 7B9M 7B9R 7B9T 7BA3 7BA5 7BA6 7BA7 7BA8 7BA9 7BAA 7BAB 7JHD 7KBS 7MSA 7N9O 7NDO 7NEL 7NFB 7NFW 7NIZ 7OPW 7OQ7 7OQ8 7PWT 7PWZ 7QVJ 7QVL 7R62 7RKE 7RNM 7RRX 7RRY 7RRZ 7RS0 7RS1 7RS2 7RS3 7RS4 7RS7 7RS8 7RS9 7SFO 7T2X 7TE7 7UJ7 7UJ8 7UJC 7UJF 7UJM 7UJO 7UJW 7UJY 7WNV 7Y8F 7Y8G 7YMK 8AFN 8AI0 8ALR 8ALT 8ALV 8ALW 8AM7 8ANF 8AOY 8APS 8AQ1 8AQC 8AQE 8AQZ 8AR4 8AR5 8ARG 8ARO 8ARQ 8ARR 8ARW 8ARX 8ARY 8ARZ 8AS1 8AT9 8ATP 8AU2 8AUS 8AUY 8AV3 8AV4 8AV7 8AV8 8AWG 8AXE 8AXU 8AZE 8B39 8BWJ 8BWX 8BWZ 8BX0 8BX3 8BX4 8BXI 8BXM 8BXN 8BXO 8BXQ 8BXS 8BY9 8BYB 8BYC 8BYD 8BYE 8BYF 8BYG 8BYO 8BYY 8BYZ 8BZ0 8BZ9 8BZA 8BZB 8BZC 8BZD 8BZE 8BZF 8BZG 8BZH 8BZT 8BZW 8C04 8C0K 8C0L 8C42 8C4F 8C4G 8DU6 8DU8 8DU9 8DUB 8DUC 8DUD 8DUG 8DUH 8DUI 8DUK 8DUS 8DV5 8DV7 8DV8 8DVB 8EV1 8EV2 8VYT 8VYX 8VZ0 8VZ1 8VZP 8VZQ 8W03 8W07 9BPX 9BQE 9BU1
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Protein Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Phosphorylation Cellular Response To Growth Factor Stimulus Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Autophosphorylation Intracellular Signaling Cassette Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Response To Lipid Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Signal Transduction Enzyme Binding Intracellular Signal Transduction Nucleotide Binding Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Protein Kinase Binding Regulation Of Signal Transduction SH2 Domain Binding Cell Population Proliferation ATP Binding Receptor Complex	Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Binding Transcription Coactivator Activity Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Intracellular Signal Transduction Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Macromolecule Metabolic Process RNA Metabolic Process DNA-templated Transcription Transcription Coregulator Activity Chromatin Organization Chromatin Remodeling Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA Binding Nuclear Estrogen Receptor Binding
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