PTPN1 and ASS1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PTPN1	ASS1
Gene Name		protein tyrosine phosphatase, non-receptor type 1	argininosuccinate synthase 1
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cytoplasmic Vesicle Sorting Endosome	Nucleus Cytoplasm Mitochondrial Outer Membrane Lysosome Endoplasmic Reticulum Cytosol Perikaryon Extracellular Vesicular Exosome Cell Body Fiber
	Molecular Function	Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Poly(A) RNA Binding Ephrin Receptor Binding	Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Poly(A) RNA Binding
	Biological Process	Blood Coagulation Insulin Receptor Signaling Pathway Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Endocytosis Platelet Activation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Actin Cytoskeleton Reorganization Peptidyl-tyrosine Dephosphorylation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development Arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Aging Response To Nutrient Response To Zinc Ion Response To Mycotoxin Response To Estradiol Cellular Nitrogen Compound Metabolic Process Response To Drug Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Growth Hormone Diaphragm Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		Interferon gamma signaling Regulation of IFNA signaling Interferon Signaling Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Regulation of IFNG signaling Growth hormone receptor signaling	Urea cycle Metabolism of amino acids and derivatives
Drugs		Tiludronate 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid Double Oxidized Cysteine Compound 12, N-Acetyl-4-[(Carboxycarbonyl)(2-Carboxyphenyl)Amino]-N-Pentyl-1-Napthylalaniamide Compound 9 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid, 2-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic Acid Compound 19 Sp7343-Sp7964 2-(Oxalyl-Amino)-Benzoic Acid {[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid) Novo Nordisk a/S Compound N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic Acid 7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid PNU177836 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide 4-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric Acid N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic Acid Cysteinesulfonic Acid 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid 4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester) 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid {4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid 2-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic Acid 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID 3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE 3(R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID ISOTHIAZOLIDINONE ANALOG 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid PARA-(BENZOYL)-PHENYLALANINE 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid	L-Arginine L-Aspartic Acid L-Citrulline Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		44 interactors: ACTN1 AKT1 ASS1 BCAR1 BCR CAPN2 CAV1 CDH2 CDK1 CLK1 CLK2 CRK CSNK2A1 CSNK2A2 CTNNB1 EGFR ESR1 GHR GLRX GRB2 GSK3B IGF1R INSR IRS1 JAK2 LAT LTK MAPK1 NFKBIA NTRK1 NTRK2 NTRK3 PDGFRB PIAS1 PIN1 RFWD2 RRAS2 SRC STAM2 STAT3 STAT5A STAT5B TRPV6 TYK2	12 interactors: AKTIP APP ARAF ASCC2 ELN JAK2 MLH1 MT2A PTPN1 TERF1 TERF2 USP4
Entrez ID		5770	445
HPRD ID		01477	04590
Ensembl ID		ENSG00000196396	ENSG00000130707
Uniprot IDs		A8K3M3 B4DSN5 P18031	B4E395 P00966 Q5T6L4
PDB IDs		1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1WAX 1XBO 2AZR 2B07 2B4S 2BGD 2BGE 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2CNE 2CNF 2CNG 2CNH 2CNI 2F6F 2F6T 2F6V 2F6W 2F6Y 2F6Z 2F70 2F71 2FJM 2FJN 2H4G 2H4K 2HB1 2HNP 2HNQ 2NT7 2NTA 2QBP 2QBQ 2QBR 2QBS 2VEU 2VEV 2VEW 2VEX 2VEY 2ZMM 2ZN7 3A5J 3A5K 3CWE 3D9C 3EAX 3EB1 3EU0 3I7Z 3I80 3QKP 3QKQ 3SME 3ZV2 4I8N	2NZ2
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of MAPK Cascade Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Hormone Peptidyl-amino Acid Modification Cellular Response To Hormone Stimulus Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Response To Peptide Response To Organonitrogen Compound Intracellular Signal Transduction Response To Growth Factor Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Response To Peptide Hormone Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Signaling Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Cell Proliferation Protein Phosphorylation Regulation Of Cellular Component Movement Regulation Of Cell Death Regulation Of Immune Response Signaling Phosphorylation Cellular Response To Stimulus Positive Regulation Of MAPK Cascade Cell Communication Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Immune System Process Regulation Of Phosphorylation Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Defense Response Regulation Of Intracellular Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Proteolysis Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Interferon-gamma-mediated Signaling Pathway Regulation Of Telomere Maintenance Cellular Copper Ion Homeostasis Cellular Response To Interferon-gamma RNA-dependent DNA Replication Regulation Of Interferon-gamma-mediated Signaling Pathway Copper Ion Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Response To Interferon-gamma Cellular Response To Growth Hormone Stimulus Regulation Of Protein Phosphorylation Telomere Maintenance Via Telomere Lengthening Regulation Of Proteasomal Protein Catabolic Process Cellular Component Assembly Response To Growth Hormone Regulation Of Binding Immune Response Negative Regulation Of Cellular Metabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA Replication Regulation Of Cellular Process Regulation Of Phosphorylation Organelle Organization Regulation Of Metabolic Process JAK-STAT Cascade Homeostatic Process Regulation Of Phosphorus Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Histone H3-Y41 Phosphorylation Meiotic Metaphase I Plate Congression Host Programmed Cell Death Induced By Symbiont Meiotic Spindle Midzone Assembly Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Cellular Localization Cell Aging
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses rca1 xpq xq25
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses rca1 xpq xq25
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