CCDC125 and FLYWCH1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC125	FLYWCH1
Description		coiled-coil domain containing 125	FLYWCH-type zinc finger 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromosome, Centromeric Region Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Pericentric Heterochromatin Cytosol Nuclear Body
	Molecular Function	Protein Binding Identical Protein Binding	Transcription Coactivator Binding DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Rho Protein Signal Transduction Activation Of GTPase Activity Regulation Of Cell Motility Negative Regulation Of Cell Motility	Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response
Pathways
Drugs
Diseases
GWAS		Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)	Post bronchodilator FEV1 ( 26634245)
Interacting Genes		64 interacting genes: AIRIM ATOSB BMP7 C21orf58 C22orf15 CCNG1 CDC23 CDK18 CEP95 DRC4 EIF3D FAM107A FAM161A FAM161B FAM47B FLYWCH1 GEM HAPLN2 HDAC4 KAT5 KIF9 KRTAP13-2 LCE2C MYH1 NEBL NSD1 NSMF OTOS PKP2 PRPF3 PTPA RAB2A RIPOR3 SFN SNW1 SPMIP2 STX11 TCHP TEAD4 TRIM14 TSGA10IP UACA YWHAE YWHAH YWHAQ YWHAZ ZFP1 ZFYVE26 ZNF165 ZNF230 ZNF250 ZNF32 ZNF337 ZNF343 ZNF417 ZNF436 ZNF552 ZNF557 ZNF564 ZNF587 ZNF764 ZNF792 ZNF837 ZNF883	14 interacting genes: CCDC125 CCDC136 ERBB3 GMCL1 GOLGA6L9 HOOK2 HSF2BP KIFC3 LHX2 MTUS2 PICK1 PPP1R16B SETDB1 TRAF2
Entrez ID		202243	84256
HPRD ID		13774	13222
Ensembl ID		ENSG00000183323	ENSG00000059122
Uniprot IDs		B4DSR1 Q2HJ12 Q86Z20	Q4VC44
PDB IDs			2RPR
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Phosphoserine Residue Binding Zinc Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Binding Transmembrane Transporter Binding
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