SRSF2 and SNRNP70

Number of citations of the paper that reports this interaction (PubMedID 29802200)
80

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SRSF2	SNRNP70
Description		serine and arginine rich splicing factor 2	small nuclear ribonucleoprotein U1 subunit 70
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol PML Body Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck Lysosomal Lumen U2-type Prespliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding U1 SnRNA Binding U1 SnRNP Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of DNA-templated Transcription	MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Cellular Response To Retinoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chaperone-mediated Autophagy
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653) Venous thromboembolism ( 33592630)
Interacting Genes		36 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIRSR CSNK2A1 DMRTB1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC PRPF6 SCAF11 SNRNP70 SREK1 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 USP40 YTHDC1 ZRANB2 ZRSR2	67 interacting genes: ADARB1 APP ARSF BACE2 CASP3 CBS CDC42 CDKL3 CEBPA CEP63 CFAP298 CHERP CRP CTDP1 DDX17 DYRK1A FTCD GATD3 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 HUNK IL32 IL7R ITSN1 LRP1 MYC NUDT21 OGT PDE9A PIGP PRKD2 PRMT5 PRPF40A PRPF6 PSMG1 RASGRF1 RBM11 RELA RIPPLY3 RNF11 RSPH1 RUNX1 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SPATC1L SRPK1 SRRM4 SRSF1 SRSF10 SRSF2 SUMO3 TIAM1 USP25 USP7 WBP4 ZRANB2
Entrez ID		6427	6625
HPRD ID		02888	01617
Ensembl ID		ENSG00000161547	ENSG00000104852
Uniprot IDs		Q01130 Q53FN0	P08621 Q9UFS1
PDB IDs		2KN4 2LEA 2LEB 2LEC	2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9 7B0Y 7VPX 8R08
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process Nuclear Speck RNA Processing Nucleic Acid Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleoplasm RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Spliceosomal Complex Nucleic Acid Binding Regulation Of MRNA Processing RNA Binding Macromolecule Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Spliceosomal Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Aggrephagy Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of Autophagy Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Regulation Of DNA Repair Regulation Of Autophagy Negative Regulation Of Catabolic Process Negative Regulation Of DNA Recombination MRNA Binding Regulation Of DNA Recombination Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Membraneless Organelle Assembly Cellular Response To Glucose Stimulus Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Sequence-specific MRNA Binding Regulation Of Hematopoietic Stem Cell Differentiation Cellular Response To Carbohydrate Stimulus	SMAD Protein Complex MRNA Processing Heteromeric SMAD Protein Complex RNA Metabolic Process RNA Processing RNA Splicing Nucleoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process I-SMAD Binding Regulation Of MRNA Splicing, Via Spliceosome SMAD Protein Signal Transduction RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Growth Factor Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Positive Regulation Of Developmental Process Identical Protein Binding Embryonic Pattern Specification Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cardiac Conduction System Development Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Transcription Spliceosomal SnRNP Assembly Nuclear Speck Positive Regulation Of Cell Differentiation Spliceosomal Complex Assembly Protein-containing Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression DEAD/H-box RNA Helicase Binding RNA Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process
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