SRSF2 and PRCC

Number of citations of the paper that reports this interaction (PMID 11313942)
6

Data Source:
HPRD (in vivo)

		SRSF2	PRCC
Gene Name		serine/arginine-rich splicing factor 2	papillary renal cell carcinoma (translocation-associated)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm PML Body Nuclear Speck Extracellular Vesicular Exosome	Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Negative Regulation Of Nucleic Acid-templated Transcription	Mitotic Cell Cycle Checkpoint
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRSF1 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2	9 interactors: CSNK2A1 EGFR LSM2 MAD2L2 PPIL2 PRPF19 RBM10 SRSF2 TOE1
Entrez ID		6427	5546
HPRD ID		02888	01562
Ensembl ID		ENSG00000161547	ENSG00000143294
Uniprot IDs		Q01130 Q53FN0	A6NG79 Q92733 Q96FT4
PDB IDs		2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process Nuclear Export Spliceosomal Complex Assembly MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Nucleocytoplasmic Transport Nuclear Transport MRNA 3'-end Processing Regulation Of MRNA Processing RNA 3'-end Processing MRNA Transport RNA Transport Cellular Macromolecular Complex Assembly RNA Localization Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Assembly Cell Cycle Regulation Of RNA Splicing Regulation Of Cell Cycle Cytoplasmic Transport Cellular Metabolic Process Mitotic Cell Cycle Cell Cycle Process Ribonucleoprotein Complex Biogenesis Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Intracellular Transport RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Component Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome DNA Strand Elongation Involved In DNA Replication Cellular Localization DNA Strand Elongation Regulation Of Protein Export From Nucleus	RNA Splicing Negative Regulation Of Protein Catabolic Process MRNA Processing Negative Regulation Of Cell Cycle Gene Expression MRNA Metabolic Process RNA Processing Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Alkanesulfonate Metabolic Process Generation Of Catalytic Spliceosome For First Transesterification Step Negative Regulation Of Chromosome Organization Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process Cell Cycle Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Double-strand Break Repair Cellular Metabolic Process Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Activation Of Phospholipase A2 Activity Negative Regulation Of APC-Cdc20 Complex Activity Cellular Aromatic Compound Metabolic Process Protein Polyubiquitination
Tagcloud ?		asxl1 biologic clonal cmml created cytopenias dependence discern dysplasia entity extramedullary extrapolation focuses granulocyte hematologic identifies landscape macrophage makes malignancy monocytosis myelomonocytic ontology propensity scientific speculative supporting tools troublesome	1g 4179delct ages bilateral develops e1351 exome germline heterozygosity hit kidneys multifocal nephrectomies nephrectomy ngs nonsilent papillary r1032 r1713h r905q rccs second seizures shower tsc tsc2 tuberous typically
Tagcloud (Difference) ?		asxl1 biologic clonal cmml created cytopenias dependence discern dysplasia entity extramedullary extrapolation focuses granulocyte hematologic identifies landscape macrophage makes malignancy monocytosis myelomonocytic ontology propensity scientific speculative supporting tools troublesome	1g 4179delct ages bilateral develops e1351 exome germline heterozygosity hit kidneys multifocal nephrectomies nephrectomy ngs nonsilent papillary r1032 r1713h r905q rccs second seizures shower tsc tsc2 tuberous typically
Tagcloud (Intersection) ?