SRSF2 and SCAF11

Number of citations of the paper that reports this interaction (PubMedID 9447963)
80

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SRSF2	SCAF11
Description		serine and arginine rich splicing factor 2	SR-related CTD associated factor 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol PML Body Nuclear Speck	Nucleus Nucleoplasm Nucleolus Nuclear Body
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of DNA-templated Transcription	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778) Fish- and plant-related diet ( 32066663) Hemoglobin levels ( 32327693) Morning person ( 30696823) Multiple sclerosis ( 31604244) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278)
Interacting Genes		36 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIRSR CSNK2A1 DMRTB1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC PRPF6 SCAF11 SNRNP70 SREK1 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 USP40 YTHDC1 ZRANB2 ZRSR2	12 interacting genes: ATXN1L PSEN1 RNF10 SNRNP70 SRPK1 SRSF1 SRSF2 SRSF3 SRSF4 STAT3 SUMO2 U2AF2
Entrez ID		6427	9169
HPRD ID		02888	04720
Ensembl ID		ENSG00000161547	ENSG00000139218
Uniprot IDs		Q01130 Q53FN0	F8VXG7 Q99590
PDB IDs		2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process Nuclear Speck RNA Processing Nucleic Acid Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleoplasm RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Spliceosomal Complex Nucleic Acid Binding Regulation Of MRNA Processing RNA Binding Macromolecule Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Spliceosomal Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Aggrephagy Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of Autophagy Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Regulation Of DNA Repair Regulation Of Autophagy Negative Regulation Of Catabolic Process Negative Regulation Of DNA Recombination MRNA Binding Regulation Of DNA Recombination Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Membraneless Organelle Assembly Cellular Response To Glucose Stimulus Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Sequence-specific MRNA Binding Regulation Of Hematopoietic Stem Cell Differentiation Cellular Response To Carbohydrate Stimulus	Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Splicing MRNA Metabolic Process Nuclear Speck MRNA Processing RNA Binding Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleus MRNA Binding RNA Processing Nucleic Acid Binding Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of RNA Splicing Postsynapse To Nucleus Signaling Pathway Regulation Of Metabolic Process Nucleoplasm Cellular Response To Interleukin-17 RNA Splicing, Via Transesterification Reactions Primary MiRNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Cytokine Sequence-specific MRNA Binding Response To Peptide Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Catabolic Process Negative Regulation Of RNA Splicing Cellular Response To Cytokine Stimulus Negative Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Positive Regulation Of ATP Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process
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