SRSF2 and CDK12

Number of citations of the paper that reports this interaction (PMID 11683387)
22

Data Source:
HPRD (in vitro, in vivo)

		SRSF2	CDK12
Gene Name		serine/arginine-rich splicing factor 2	cyclin-dependent kinase 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm PML Body Nuclear Speck Extracellular Vesicular Exosome	Cyclin K-CDK12 Complex Nucleus Nucleoplasm Nucleolus Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex
	Molecular Function	Nucleotide Binding Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Cyclin Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Negative Regulation Of Nucleic Acid-templated Transcription	MRNA Processing RNA Splicing Regulation Of MAP Kinase Activity Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRSF1 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2	7 interactors: EWSR1 MBP PIN1 POLR2A PRPF40A SRSF1 SRSF2
Entrez ID		6427	51755
HPRD ID		02888	10849
Ensembl ID		ENSG00000161547	ENSG00000167258
Uniprot IDs		Q01130 Q53FN0	Q9NYV4
PDB IDs		2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process Nuclear Export Spliceosomal Complex Assembly MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Nucleocytoplasmic Transport Nuclear Transport MRNA 3'-end Processing Regulation Of MRNA Processing RNA 3'-end Processing MRNA Transport RNA Transport Cellular Macromolecular Complex Assembly RNA Localization Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Assembly Cell Cycle Regulation Of RNA Splicing Regulation Of Cell Cycle Cytoplasmic Transport Cellular Metabolic Process Mitotic Cell Cycle Cell Cycle Process Ribonucleoprotein Complex Biogenesis Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Intracellular Transport RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Component Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome DNA Strand Elongation Involved In DNA Replication Cellular Localization DNA Strand Elongation Regulation Of Protein Export From Nucleus	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Termination Of RNA Polymerase II Transcription Regulation Of Cytokinesis MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Regulation Of RNA Splicing RNA 3'-end Processing Nuclear Export MRNA Transport Transcription, RNA-templated RNA Transport RNA Metabolic Process RNA Localization Defense Response To Nematode Gene Expression MRNA 5'-splice Site Recognition Transcription From RNA Polymerase II Promoter Negative Regulation Of Cytokine Production Response To Nematode Regulation Of Cell Division Transcription, DNA-templated Nucleocytoplasmic Transport Nuclear Transport RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Interleukin-10 Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process MRNA Cis Splicing, Via Spliceosome Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Interleukin-4 Production Response To Mercury Ion Regulation Of Cell Morphogenesis Regulation Of Cellular Process Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process 7-methylguanosine MRNA Capping Regulation Of Interleukin-4 Production PiRNA Metabolic Process Regulation Of Cytokine Production Positive Regulation Of RNA Splicing 7-methylguanosine RNA Capping Substantia Nigra Development
Tagcloud ?		asxl1 biologic clonal cmml created cytopenias dependence discern dysplasia entity extramedullary extrapolation focuses granulocyte hematologic identifies landscape macrophage makes malignancy monocytosis myelomonocytic ontology propensity scientific speculative supporting tools troublesome	affects associate bulk ccnk cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Difference) ?		asxl1 biologic clonal cmml created cytopenias dependence discern dysplasia entity extramedullary extrapolation focuses granulocyte hematologic identifies landscape macrophage makes malignancy monocytosis myelomonocytic ontology propensity scientific speculative supporting tools troublesome	affects associate bulk ccnk cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Intersection) ?