SRSF2 and NCF1

Number of citations of the paper that reports this interaction (PubMedID 16052631)
0

Data Source:
BioGRID (two hybrid)

		SRSF2	NCF1
Description		serine and arginine rich splicing factor 2	neutrophil cytosolic factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol PML Body Nuclear Speck	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding	Protein Binding Lipid Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of DNA-templated Transcription	Response To Yeast Leukocyte Mediated Cytotoxicity Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Inflammatory Response Cellular Defense Response Response To Bacterium Superoxide Anion Generation Defense Response To Bacterium Innate Immune Response Respiratory Burst Hydrogen Peroxide Biosynthetic Process Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Defense Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Fungus Cellular Response To Glucose Stimulus Cellular Response To Testosterone Stimulus Reactive Oxygen Species Metabolic Process Reactive Oxygen Species Biosynthetic Process
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs			Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS			Systemic lupus erythematosus ( 33493351)
Interacting Genes		36 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIRSR CSNK2A1 DMRTB1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC PRPF6 SCAF11 SNRNP70 SREK1 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 USP40 YTHDC1 ZRANB2 ZRSR2	29 interacting genes: ACTB CEBPA CSNK2B FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN RB1 SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		6427	653361
HPRD ID		02888
Ensembl ID		ENSG00000161547	ENSG00000158517
Uniprot IDs		Q01130 Q53FN0	P14598
PDB IDs		2KN4 2LEA 2LEB 2LEC	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP 7YXW 8WEJ
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process Nuclear Speck RNA Processing Nucleic Acid Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleoplasm RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Spliceosomal Complex Nucleic Acid Binding Regulation Of MRNA Processing RNA Binding Macromolecule Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Spliceosomal Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Aggrephagy Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of Autophagy Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Regulation Of DNA Repair Regulation Of Autophagy Negative Regulation Of Catabolic Process Negative Regulation Of DNA Recombination MRNA Binding Regulation Of DNA Recombination Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Membraneless Organelle Assembly Cellular Response To Glucose Stimulus Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Sequence-specific MRNA Binding Regulation Of Hematopoietic Stem Cell Differentiation Cellular Response To Carbohydrate Stimulus	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Enzyme Binding Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Immune System Process Cytosol Protein Phosphorylation Protein Domain Specific Binding Regulation Of Protein Metabolic Process Phosphorylation Maltose Metabolic Process NADPH Oxidase Complex Histone H3T6 Kinase Activity Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Regulation Of Hemopoiesis Regulation Of G1/S Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Regulation Of Cell Activation Alpha-1,4-glucosidase Activity Superoxide Anion Generation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Positive Regulation Of Leukocyte Differentiation Alpha-glucosidase Activity Phagolysosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Rb-E2F Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport Regulation Of Cell Development Superoxide Metabolic Process Plasma Membrane Extracellular Exosome Response To Hormone Nuclear Matrix Regulation Of Multicellular Organismal Development
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