U2AF2 and QKI

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		U2AF2	QKI
Description		U2 small nuclear RNA auxiliary factor 2	QKI, KH domain containing RNA binding
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GO Annotations	Cellular Component	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding Molecular Function Inhibitor Activity	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding SH3 Domain Binding MiRNA Binding Internal N(7)-methylguanine-containing RNA Reader Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome	Vasculogenesis MRNA Processing Regulation Of Translation Spermatid Development Intracellular MRNA Localization Axon Ensheathment RNA Splicing Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Microglia Differentiation Negative Regulation Of Angiogenesis Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Myelination Negative Regulation Of Type I Interferon Production Stress Granule Assembly Vascular Associated Smooth Muscle Cell Differentiation Myelination Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macrophage Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Regulation Of Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation MRNA Transport Regulation Of Cell Development Negative Regulation Of Cold-induced Thermogenesis Spliceosome-depend Formation Of Circular RNA Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Myofibroblast Contraction Regulation Of Multicellular Organismal Development Negative Regulation Of MiRNA Catabolic Process
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Protein hydroxylation	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)	Cataracts ( 34127677) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Fasting insulin ( 34059833) Height ( 31562340) Hemoglobin ( 32888494) Incident myocardial infarction ( 26950853) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Platelet distribution width ( 32888494) Red blood cell count ( 29403010) Refractive error ( 32231278) Response to TNF antagonist treatment ( 18615156) Seasonality and depression ( 30217971) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 30718926)
Interacting Genes		71 interacting genes: - APBB1 ATXN1 BEND7 CCAR1 CDC42 CHIC2 CPSF7 DACH1 DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OGT OTUB2 PHF5A PIN1 POLR2A PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B3 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 USP7 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1	90 interacting genes: ALG13 ANKHD1 APP ATXN1 BAG4 BCAS2 CALD1 CARM1 CCDC59 CCND3 CDKN2D CEBPA CPSF7 DAZ1 DAZ4 DEPP1 DMRTB1 EIF4ENIF1 FBXO7 FHL3 FUBP3 HCLS1 HLCS HNRNPH2 HNRNPK HNRNPLL IL7R KIF21B LSM3 LSM5 MBNL1 MBNL2 MIR141 MIR19B2 MIR200A MIR34B MIR34C MIR7-1 MRPL44 MSI2 NABP1 NEIL3 NIP7 NXF1 PCBP1 PCBP2 PCBP3 PCBP4 PCGF5 PIAS1 PRKAB2 PRMT1 PRPF39 PRPF6 PRRC2B PSMF1 PTBP1 PTBP2 RALY RBFOX1 RBFOX2 RBM11 RBM14 RBM23 RBM42 RBM7 RBPMS RNF138 RPL9 SECISBP2 SERF2 SLAIN1 SNRPA SNRPC TEX11 THAP1 TIAL1 TNRC6A TRNAU1AP TSG101 TXNL4A U2AF2 UNKL USH1C UTP6 WDR77 YTHDF1 YTHDF3 ZC3H10 ZMAT5
Entrez ID		11338	9444
HPRD ID		01872	06691
Ensembl ID		ENSG00000063244	ENSG00000112531
Uniprot IDs		P26368	Q8WY44 Q96PU8
PDB IDs		1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX 7S3A 7S3B 7S3C 7SN6 8P25 9C7A 9C7B 9DWU	4JVH
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Binding RNA Metabolic Process Nucleic Acid Binding Nucleoplasm Regulation Of RNA Splicing Nucleic Acid Metabolic Process Nucleus Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process U2AF Complex Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Positive Regulation Of Biosynthetic Process RS Domain Binding Pre-mRNA 3'-splice Site Binding Protein-containing Complex Assembly U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex MRNA Splice Site Recognition Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Splicing	RNA Binding Nucleic Acid Binding Regulation Of RNA Splicing MRNA Binding RNA Splicing Regulation Of MRNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Processing RNA Metabolic Process Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleoplasm Negative Regulation Of RNA Splicing Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process MRNA 3'-UTR Binding Cytoplasmic Stress Granule Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Commitment Complex Regulation Of Translation Viral RNA Genome Replication Regulation Of MRNA Stability Negative Regulation Of RNA Metabolic Process
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