U2AF2 and CCAR1

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		U2AF2	CCAR1
Gene Name		U2 small nuclear RNA auxiliary factor 2	cell division cycle and apoptosis regulator 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleoplasm Spliceosomal Complex Nuclear Speck	Nucleoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding Enzyme Binding Poly(A) RNA Binding C2H2 Zinc Finger Domain Binding	Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cell Cycle RNA Splicing Gene Expression
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		51 interactors: AES APBB1 ATXN1 BEND7 CCAR1 CHERP CHIC2 CPSF7 DACH1 DDX17 DDX6 DPPA2 DVL2 EPB41 GEMIN2 GLIS2 HLA-DMA HNRNPA0 HNRNPD HNRNPK IL7R KHDRBS1 KHDRBS3 KIAA0907 LURAP1 MAP1B PIN1 POLR2A PRPF3 PRPF40A PUF60 QKI RBFOX2 RBM39 RBM4 SAP30BP SCAF11 SF1 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SUGP1 TCERG1 THAP1 TOP1 U2AF1 WT1 ZRSR2	10 interactors: CASP10 CHERP GOLGA2 HNRNPK MDM2 PIH1D3 RBM10 RNF113A SFN U2AF2
Entrez ID		11338	55749
HPRD ID		01872	10811
Ensembl ID		ENSG00000063244	ENSG00000060339
Uniprot IDs		P26368	Q8IX12
PDB IDs		1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW
Enriched GO Terms of Interacting Partners?		RNA Processing RNA Splicing MRNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Biosynthetic Process Spliceosomal Complex Assembly Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Biogenesis Cellular Macromolecular Complex Assembly Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Metabolic Process Regulation Of MRNA Processing Termination Of RNA Polymerase II Transcription Regulation Of MRNA Stability Regulation Of RNA Stability Cellular Process DNA-templated Transcription, Termination Regulation Of Translation MRNA 3'-end Processing Positive Regulation Of Macromolecule Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Female Gonad Development Circadian Regulation Of Translation RNA 3'-end Processing	Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Protein Transport RNA Processing Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Transport RNA Splicing Cellular Response To UV-C Cellular Response To Vitamin B1 MRNA Processing Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Intracellular Transport Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Metabolic Process Regulation Of Epidermal Cell Division Regulation Of Protein Transport Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Establishment Of Protein Localization Response To Vitamin B1 Response To Ether Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Localization Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of NFAT Protein Import Into Nucleus Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process Response To UV-C Keratinocyte Development Negative Regulation Of Endopeptidase Activity Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Peptidase Activity Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Programmed Cell Death Regulation Of Cellular Localization Axonemal Dynein Complex Assembly Cell Death Death Regulation Of Receptor Biosynthetic Process Establishment Of Skin Barrier
Tagcloud ?		acceptor accessory advance alters codons corroborated cytidine doi junctions leu missense november novo online publication q157 q157p q157r s34 s34f s34y seq snrnp speckles splice splicing u2af1 uridine	alleles architecture cdkn1b chd1 copy damaging drivers encompassing exome foxa1 genotyping heterozygosity interpret interpretation kip1 loh manage mosaicism mutational personalized rb1 retained scpc somatic suppressors tp53 underscores virchow widespread
Tagcloud (Difference) ?		acceptor accessory advance alters codons corroborated cytidine doi junctions leu missense november novo online publication q157 q157p q157r s34 s34f s34y seq snrnp speckles splice splicing u2af1 uridine	alleles architecture cdkn1b chd1 copy damaging drivers encompassing exome foxa1 genotyping heterozygosity interpret interpretation kip1 loh manage mosaicism mutational personalized rb1 retained scpc somatic suppressors tp53 underscores virchow widespread
Tagcloud (Intersection) ?