FUS and MAX

Number of citations: 57 (PubMedID 20195357)
Data Source: BioGRID (pull down)

		FUS	MAX
Name		FUS RNA binding protein	MYC associated factor X
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Chromatin Nucleus Nucleoplasm Dendrite Protein-DNA Complex Cell Projection Mad-Max Complex MLL1 Complex Myc-Max Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Molecular Condensate Scaffold Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Splicing Gene Expression Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription MRNA Stabilization Protein Homooligomerization Membraneless Organelle Assembly Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Amyloid Fibril Formation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Transcription of E2F targets under negative control by DREAM complex Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6
Diseases		Myxoid liposarcoma Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease	None
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) HDL cholesterol levels ( 32203549 )	Anthropometric traits ( 19260139 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Blood trace element (Zn levels) ( 23720494 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Height ( 31562340 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil count ( 32888494 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 27863252 ) Red blood cell count ( 27863252 32888494 ) Red blood cell traits ( 23222517 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		122 interacting genes: ADAMTS9-AS2 AKT1 ARID1A ATM ATXN1L BACH2 BCL2L13 CEBPA CREBBP CTNNB1 ESRRA FNDC3B GRIN1 GRIN2D IL7R ILF3 ISG15 KHDRBS3 MAX MDH1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NKD2 OGT PDE4B POLR2A PRMT1 PSMB7 PTBP1 RELA RXRA SAFB2 SF1 SFPQ SMARCB1 SMARCC1 SMARCC2 SMARCD1 SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SS18 SUV39H1 TDRD3 THRA UBQLN2 WBP4 YBX1 ZMYM2	43 interacting genes: BANP CASP5 CASP7 CLIP2 COPS5 CSNK2A1 CUX1 EP300 EPAS1 FTH1 FUS GABBR1 HIF1A MAD1L1 MAPK14 MGA MNT MSH2 MXD1 MXD3 MXD4 MXI1 MYC MYCL MYCLP1 MYCN PLEKHA5 PLEKHF2 PLIN3 RPL34 RPL35 SMAD3 SMAD4 SNIP1 SPAG9 TAF1 TEAD1 TRRAP TUBA1A TXLNG UNC45A USP1 ZBTB17
Entrez ID		2521	4149
HPRD ID		00660	01113
Ensembl ID		ENSG00000089280	ENSG00000125952
Uniprot IDs		A0AAQ5BIG2 P35637 Q13344 Q6IBQ5	G3V302 G3V563 G3V5L1 P61244 Q6V3B1 Q8TAX8
PDB IDs		2LA6 2LCW 4FDD 4FQ3 5W3N 5XRR 5XSG 5YVG 5YVH 5YVI 6BWZ 6BXV 6BZP 6G99 6GBM 6KJ1 6KJ2 6KJ3 6KJ4 6SNJ 6XFM 7CYL 7VQQ	1AN2 1HLO 1NKP 1NLW 1R05 5EYO 6G6J 6G6K 6G6L 8OTS 8OTT
GO Terms Enriched among Interactors		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Translation Extracellular Vesicle MRNA Destabilization RNA Destabilization Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Negative Regulation Of Locomotion Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Multicellular Organismal Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Protein Dimerization Activity Chromatin Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Binding Nucleoplasm DNA Binding Positive Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of MiRNA Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Light Stimulus Regulation Of MiRNA Metabolic Process Response To UV Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transforming Growth Factor Beta2 Production Response To Radiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Binding Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Neddylation Positive Regulation Of RNA Metabolic Process Intracellular Iron Ion Homeostasis Regulation Of Macromolecule Metabolic Process Striated Muscle Cell Differentiation Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process