FUS and GRIN2D

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		FUS	GRIN2D
Gene Name		FUS RNA binding protein	glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Plasma Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Postsynaptic Membrane
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression	Startle Response Signal Transduction Synaptic Transmission Adult Locomotory Behavior Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Sensory Perception Of Pain
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Orphenadrine Tenocyclidine
Diseases
GWAS
Protein-Protein Interactions		39 interactors: ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 NKD2 NUPR1 PA2G4 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SUV39H1 TAF15 TARDBP TDRD3 THRA TNIP1 WBP4 YBX1 ZMYM2	33 interactors: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA INADL MAP2 MAP2K2 NANOS1 NF1 PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		2521	2906
HPRD ID		00660	04095
Ensembl ID		ENSG00000089280	ENSG00000105464
Uniprot IDs		P35637 Q13344 Q6IBQ5	O15399 Q59G17
PDB IDs		2LA6 2LCW 4FDD 4FQ3
Enriched GO Terms of Interacting Partners?		Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process RNA Splicing Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Processing Transcription From RNA Polymerase II Promoter Biosynthetic Process MRNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Splicing Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription, DNA-templated MRNA Export From Nucleus RNA Export From Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter	Nervous System Development Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Cell Development Locomotion Generation Of Neurons Intracellular Signal Transduction Neuron Projection Development Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Cellular Response To Stimulus Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Organization Signaling Cell Morphogenesis Involved In Differentiation Axonogenesis MyD88-independent Toll-like Receptor Signaling Pathway Neuron Development Cell Communication Apoptotic Process Response To Organic Substance Signal Transduction Axon Guidance Axon Development Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Death Toll-like Receptor 4 Signaling Pathway Death Regulation Of Neuron Death Developmental Process Neuron Projection Morphogenesis Response To Ammonium Ion Immune Response-regulating Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Response To Morphine Regulation Of Intracellular Signal Transduction Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development Response To External Stimulus Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?