FUS and ILF3

Number of citations of the paper that reports this interaction (PubMedID 11438536)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		FUS	ILF3
Description		FUS RNA binding protein	interleukin enhancer binding factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Molecular Condensate Scaffold Activity	Virus Receptor Activity DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Splicing Gene Expression Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription MRNA Stabilization Protein Homooligomerization Membraneless Organelle Assembly Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Amyloid Fibril Formation	Protein Phosphorylation Negative Regulation Of Translation Negative Regulation Of Viral Genome Replication Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Defense Response To Virus Spliceosome-depend Formation Of Circular RNA
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription PKR-mediated signaling
Drugs
Diseases		Myxoid liposarcoma Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) HDL cholesterol levels ( 32203549)	Bipolar disorder ( 31043756) Chronotype ( 30696823) Height ( 25282103 25429064) Obesity-related traits ( 23251661) Psoriasis ( 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 30423114) Systemic lupus erythematosus ( 28714469)
Interacting Genes		122 interacting genes: ADAMTS9-AS2 AKT1 ARID1A ATM ATXN1L BACH2 BCL2L13 CEBPA CREBBP CTNNB1 ESRRA FNDC3B GRIN1 GRIN2D IL7R ILF3 ISG15 KHDRBS3 MAX MDH1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NKD2 OGT PDE4B POLR2A PRMT1 PSMB7 PTBP1 RELA RXRA SAFB2 SF1 SFPQ SMARCB1 SMARCC1 SMARCC2 SMARCD1 SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SS18 SUV39H1 TDRD3 THRA UBQLN2 WBP4 YBX1 ZMYM2	44 interacting genes: CEBPA DHX9 DUX4 EIF2AK2 EP300 ERBB2 ERG ESR1 FUS GDF9 HNRNPH2 IL7R IRF3 IRF9 KRTAP4-12 LINC00624 LNX1 MAGEA11 MAPK1 MDFI NDRG1 OGT PLSCR1 PRMT1 PRMT5 PSMA3 PTEN RBM5 RBPMS SF1 SF3B4 SMN1 SPOP TRIM55 TRIM63 TRIP6 UBC USP7 VPS37C XAB2 XPO5 YWHAH ZNF346 ZNF830
Entrez ID		2521	3609
HPRD ID		00660	04420
Ensembl ID		ENSG00000089280	ENSG00000129351
Uniprot IDs		A0AAQ5BIG2 P35637 Q13344 Q6IBQ5	Q12906
PDB IDs		2LA6 2LCW 4FDD 4FQ3 5W3N 5XRR 5XSG 5YVG 5YVH 5YVI 6BWZ 6BXV 6BZP 6G99 6GBM 6KJ1 6KJ2 6KJ3 6KJ4 6SNJ 6XFM 7CYL 7VQQ	2L33 3P1X 7RJM 7RJQ
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Translation Extracellular Vesicle MRNA Destabilization RNA Destabilization Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Negative Regulation Of Locomotion Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Multicellular Organismal Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding RNA Splicing Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein-RNA Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Cytoplasm Positive Regulation Of RNA Metabolic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Assembly Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleic Acid Binding Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions DNA-templated Transcription Termination RNA Binding Nucleic Acid Metabolic Process TORC1 Signaling Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Population Proliferation Macromolecule Biosynthetic Process Cellular Component Assembly RNA Processing Cellular Response To Nutrient Levels Protein-containing Complex Assembly RISC Complex Binding Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation TOR Signaling Chromatin DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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