CRLF2 and IL7R

Number of citations of the paper that reports this interaction (PMID 11418668)
74

Data Source:
HPRD (in vivo)

		CRLF2	IL7R
Gene Name		cytokine receptor-like factor 2	interleukin 7 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function		Antigen Binding Interleukin-7 Receptor Activity Protein Binding
	Biological Process		Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells
Pathways			Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		3 interactors: IL7R JAK2 TSLP	104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		64109	3575
HPRD ID		02288	00893
Ensembl ID		ENSG00000205755	ENSG00000168685
Uniprot IDs		D0E2W4 Q5G7M1 Q9HC73	D6RGV2 D9N160 P16871
PDB IDs			3DI2 3DI3 3UP1
Enriched GO Terms of Interacting Partners?		Host Programmed Cell Death Induced By Symbiont Histone H3-Y41 Phosphorylation Homeostasis Of Number Of Cells Interleukin-7-mediated Signaling Pathway Mineralocorticoid Receptor Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Interleukin-12-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Cytokine-mediated Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway STAT Protein Import Into Nucleus Negative Regulation Of T Cell Mediated Cytotoxicity Response To Interleukin-12 Regulation Of Cell Activation Tyrosine Phosphorylation Of Stat3 Protein Activation Of Janus Kinase Activity Cellular Response To Cytokine Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Cell Adhesion Hemopoiesis Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Immune System Development Response To Cytokine Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Differentiation Regulation Of Immune Response Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Response To Hydroperoxide Negative Regulation Of Heart Contraction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Growth Hormone Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of Interleukin-1 Beta Production Regulation Of Tyrosine Phosphorylation Of Stat3 Protein	MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation
Tagcloud ?		acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il15ra il1a il1b il23a il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il15ra il1a il1b il23a il2ra il6 il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?		il7r