SAMSN1 and FASLG

Number of citations of the paper that reports this interaction (PMID 19807924)
2

Data Source:
BioGRID (unspecified method)

		SAMSN1	FASLG
Gene Name		SAM domain, SH3 domain and nuclear localization signals 1	Fas ligand (TNF superfamily, member 6)
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytosol	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome
	Molecular Function	Phosphotyrosine Binding Poly(A) RNA Binding	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Adaptive Immune Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of B Cell Activation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		10 interactors: FASLG NEDD4 PILRB SAP30 SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ	74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1
Entrez ID		64092	356
HPRD ID		06413	00610
Ensembl ID		ENSG00000155307	ENSG00000117560
Uniprot IDs		F8WAA1 Q9NSI8	P48023 Q53ZZ1
PDB IDs		2KEA	1BZI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Transport Positive Regulation Of Organelle Organization Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Regulation Of Apoptotic Process Protein Targeting Membrane Organization Substantia Nigra Development Regulation Of Cell Death Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Signal Transduction Neural Nucleus Development Negative Regulation Of Protein Dephosphorylation Regulation Of Cellular Component Organization Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Glucocorticoid Receptor Signaling Pathway Midbrain Development Cellular Protein Localization Protein Transport Establishment Of Protein Localization Signal Transduction Intracellular Transport Signaling Cell Communication Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity System Development Intracellular Signal Transduction Negative Regulation Of Transcription, DNA-templated	Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway
Tagcloud ?		11q 13q 14q 15q 1q 21q 22q 2q 3q 4p 4q 9q acgh acsl1 atp8b4 bcl1 fbxl5 imbalances irf2bp2 ivns1abp jh lamp2 myeloma nampt picalm q13 q32 stk17b xq	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable
Tagcloud (Difference) ?		11q 13q 14q 15q 1q 21q 22q 2q 3q 4p 4q 9q acgh acsl1 atp8b4 bcl1 fbxl5 imbalances irf2bp2 ivns1abp jh lamp2 myeloma nampt picalm q13 q32 stk17b xq	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable
Tagcloud (Intersection) ?