VTI1B and STX8

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo)

		VTI1B	STX8
Gene Name		vesicle transport through interaction with t-SNAREs 1B	syntaxin 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane SNARE Complex Late Endosome Membrane Vesicle Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome	Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Integral Component Of Plasma Membrane SNARE Complex Late Endosome Membrane Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	SNARE Binding SNAP Receptor Activity Chloride Channel Inhibitor Activity	SNAP Receptor Activity Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Autophagic Vacuole Fusion Protein Targeting To Vacuole ER To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Cell Proliferation Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Regulation Of Protein Localization To Plasma Membrane	Transport Intracellular Protein Transport Vesicle Fusion Endosome To Lysosome Transport Early Endosome To Late Endosome Transport Regulation Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: GOLGB1 KRTAP10-7 LDLRAD1 PTPN5 STX4 STX7 STX8 SYNE4 TNK2 TRIM59	17 interactors: ACVR1 CALM1 CLN8 COPA CREB3 NAPA NAPG NSF STX1A STX4 STX7 TGFBR1 UBC VPS11 VPS18 VTI1B WDR91
Entrez ID		10490	9482
HPRD ID		04440	05012
Ensembl ID		ENSG00000100568
Uniprot IDs		Q9UEU0	Q9UNK0
PDB IDs		2V8S
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Regulation Of Protein Localization To Plasma Membrane Organelle Fusion Membrane Fusion Vesicle Organization Vesicle Docking Positive Regulation Of Receptor Localization To Synapse Membrane Docking Positive Regulation Of Eosinophil Degranulation Vesicle-mediated Transport Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Localization Membrane Organization Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization To Cell Surface Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Intracellular Protein Transport Positive Regulation Of Immunoglobulin Secretion SNARE Complex Assembly Establishment Of Monopolar Cell Polarity Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Cellular Localization Regulation Of Clathrin-mediated Endocytosis Regulation Of Immunoglobulin Secretion Establishment Of Epithelial Cell Polarity Regulation Of Vesicle-mediated Transport Regulation Of Protein Localization To Cell Surface Positive Regulation Of Regulated Secretory Pathway Early Endosome To Late Endosome Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Hydroperoxide Organelle Localization Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Morphogenesis Of A Polarized Epithelium Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cellular Protein Localization Positive Regulation Of Protein Localization To Plasma Membrane Protein Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Endosome To Lysosome Transport Establishment Of Protein Localization Intracellular Transport Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immunoglobulin Production Regulation Of Regulated Secretory Pathway Organelle Organization	Membrane Organization Membrane Fusion Vesicle Docking Membrane Docking Intracellular Protein Transport Cellular Localization Cellular Protein Localization Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Cellular Localization Golgi Vesicle Transport Vesicle Fusion Intra-Golgi Vesicle-mediated Transport Exocytosis Secretion Organelle Fusion Vesicle Organization Post-Golgi Vesicle-mediated Transport Transport Secretion By Cell Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Priming Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization Vesicle Docking Involved In Exocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Pharyngeal System Development Positive Regulation Of Transport Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neurotransmitter Levels Organelle Localization Activin Receptor Signaling Pathway Neurotransmitter Transport Regulation Of Synaptic Vesicle Exocytosis Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Apoptotic Process Cell-cell Signaling Negative Regulation Of Apoptotic Process Response To Transforming Growth Factor Beta
Tagcloud ?		autophagic autophagolysosomal bacterium biogenesis burnetii chloramphenicol colocalization coxiella crv crvs endocytic endolysosomal facilitating favours heterotypic homotypic lysosomes nt phagolysosomal phagosomes replicative snare snares vacuole vacuoles vamp3 vamp7 vamp8 vti1a	cd3 ctls eliminate exocytosis granules granzymes groundwork laying lgs lytic nsf perforin snap snare snares stx13 stx16 stx3 stx4 stx6 stx7 synapse synapses syntaxin1b2 tumorigenic vamp3 vamp4 vesicle vti1b
Tagcloud (Difference) ?		autophagic autophagolysosomal bacterium biogenesis burnetii chloramphenicol colocalization coxiella crv crvs endocytic endolysosomal facilitating favours heterotypic homotypic lysosomes nt phagolysosomal phagosomes replicative vacuole vacuoles vamp7 vamp8 vti1a	cd3 ctls eliminate exocytosis granules granzymes groundwork laying lgs lytic nsf perforin snap stx13 stx16 stx3 stx4 stx6 stx7 synapse synapses syntaxin1b2 tumorigenic vamp4 vesicle
Tagcloud (Intersection) ?		snare snares vamp3 vti1b