VTI1B and MANBAL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VTI1B	MANBAL
Description		vesicle transport through interaction with t-SNAREs 1B	mannosidase beta like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Platelet Alpha Granule Lumen SNARE Complex Early Endosome Membrane Late Endosome Membrane Vesicle Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Presynaptic Endosome Membrane	Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Protein Transport Vesicle-mediated Transport Macroautophagy Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Appendicular lean mass ( 33097823)
Interacting Genes		38 interacting genes: AQP6 ASGR2 BIK CD46 CD79A CFTR CRB3 CREB3 ERGIC3 FCGR1A GOLGB1 GPR35 GPX8 JAGN1 KASH5 KLRC1 KRTAP10-7 LDLRAD1 LMNA MANBAL PTPN5 REEP4 RNASEK SAR1A SLC16A7 SLC18A1 SLC35H1 STX1A STX2 STX4 STX7 STX8 SYNE4 TMEM14B TMEM234 TMEM51 TNK2 TRIM59	21 interacting genes: ATP13A1 CACNA1A CATSPERH CMTM2 GPR151 KLK5 MALL MARCHF5 MPDU1 NIPAL3 OTOP2 PIGF SCRG1 SLC39A9 STX3 TMBIM6 TMEM115 TMEM203 UBQLN1 VKORC1 VTI1B
Entrez ID		10490	63905
HPRD ID		04440	14356
Ensembl ID		ENSG00000100568	ENSG00000101363
Uniprot IDs		Q9UEU0	A2A2E0 Q9NQG1
PDB IDs		2V8S
Enriched GO Terms of Interacting Partners?		Membrane Chloride Channel Inhibitor Activity Vesicle Docking Organelle Localization By Membrane Tethering SNAP Receptor Activity Membrane Docking SNARE Complex SNARE Binding Vesicle-mediated Transport Endomembrane System Vesicle Fusion Organelle Membrane Fusion Organelle Localization Membrane Organization Organelle Fusion Membrane Fusion Vesicle Organization Cornified Envelope Assembly Intracellular Protein Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Membrane Assembly Positive Regulation Of Immune Effector Process SNARE Complex Assembly Endoplasmic Reticulum Membrane Regulation Of Insulin Secretion Regulation Of Protein Localization Regulation Of Peptide Hormone Secretion Regulation Of Cellular Localization Positive Regulation Of Exocytosis Exocytosis Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Nuclear Envelope Organization Protein Binding Water Transport Endoplasmic Reticulum Regulation Of Adaptive Immune Response Neurotransmitter Transport Schaffer Collateral - CA1 Synapse Establishment Of Localization In Cell Nitrate Transmembrane Transporter Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Basolateral Plasma Membrane Protein Transport Presynaptic Active Zone Membrane High-affinity IgG Receptor Activity Inhibitory MHC Class Ib Receptor Activity	Membrane Endoplasmic Reticulum Membrane Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Monoatomic Ion Transport Metal Ion Transport Endoplasmic Reticulum SNARE Complex Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane SNAP Receptor Activity Intracellular Calcium Ion Homeostasis Endoribonuclease Inhibitor Activity Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Negative Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Autophagosome Maturation Presynaptic Endosome Membrane Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vesicle Docking Monoatomic Ion Homeostasis SNARE Binding Negative Regulation Of Cation Transmembrane Transport Chemical Homeostasis Ethanolaminephosphotransferase Activity Intracellular Chemical Homeostasis Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Toll-like Receptor 3 Signaling Pathway P-type Transmembrane Transporter Activity
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