CXCL6 and CXCR1

Number of citations of the paper that reports this interaction (PMID 9692902)
19

Data Source:
HPRD (in vivo)

		CXCL6	CXCR1
Gene Name		chemokine (C-X-C motif) ligand 6	chemokine (C-X-C motif) receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding	Interleukin-8 Receptor Activity G-protein Coupled Receptor Activity Chemokine Receptor Activity Interleukin-8 Binding
	Biological Process	Neutrophil Mediated Immunity Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Lipopolysaccharide Regulation Of Cell Proliferation Defense Response To Bacterium Cell Chemotaxis Chemokine-mediated Signaling Pathway	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)
Protein-Protein Interactions		3 interactors: CXCR1 CXCR2 MMP9	16 interactors: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C
Entrez ID		6372	3577
HPRD ID		00735	00908
Ensembl ID		ENSG00000124875	ENSG00000163464
Uniprot IDs		P80162	P25024
PDB IDs			1ILP 1ILQ 2LNL
Enriched GO Terms of Interacting Partners?		Interleukin-8-mediated Signaling Pathway Leukocyte Migration Dendritic Cell Chemotaxis Dendritic Cell Migration Receptor Internalization Chemokine-mediated Signaling Pathway Chemotaxis Receptor Metabolic Process Cell Migration Leukocyte Chemotaxis Cell Motility Negative Regulation Of Neutrophil Apoptotic Process Cell Chemotaxis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Receptor Binding Response To External Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Receptor-mediated Endocytosis Acute Inflammatory Response To Antigenic Stimulus Immune System Process Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Vascular Permeability Metanephric Tubule Morphogenesis Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Cell Death Regulation Of Cell Motility Endocytosis Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Negative Regulation Of Cation Channel Activity Macrophage Differentiation Regulation Of Cellular Component Movement Positive Regulation Of Neutrophil Chemotaxis Response To Cytokine Neutrophil Activation Positive Regulation Of Granulocyte Chemotaxis Regulation Of Neutrophil Chemotaxis Metanephric Epithelium Development Regulation Of Neutrophil Migration	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Inflammatory Response Response To Cytokine Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Lipopolysaccharide Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Bacterium Locomotion Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Organic Substance Response To Organic Substance Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Stress Movement Of Cell Or Subcellular Component Response To Other Organism Response To Biotic Stimulus Response To Lipid Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Tagcloud ?		act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl2 cxcl5 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	ab attenuating chemokine chemokines chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Difference) ?		act1 alpha blot ccl20 changed cultured cxcl1 cxcl2 cxcl5 declined ht il intestinal knockdown line obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	ab attenuating chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Intersection) ?		chemokine chemokines neutrophil