CXCL6 and MMP9

Number of citations of the paper that reports this interaction (PMID 12950257)
48

Data Source:
BioGRID (enzymatic study)

		CXCL6	MMP9
Gene Name		chemokine (C-X-C motif) ligand 6	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Collagen Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Neutrophil Mediated Immunity Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Lipopolysaccharide Regulation Of Cell Proliferation Defense Response To Bacterium Cell Chemotaxis Chemokine-mediated Signaling Pathway	Skeletal System Development Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Positive Regulation Of Receptor Binding Negative Regulation Of Cation Channel Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Signaling by SCF-KIT EPH-ephrin mediated repulsion of cells Axon guidance Collagen formation Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs			Marimastat Minocycline Captopril Glucosamine 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		3 interactors: CXCR1 CXCR2 MMP9	32 interactors: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFB1 THBS1 THBS2 TIMP3
Entrez ID		6372	4318
HPRD ID		00735	00387
Ensembl ID		ENSG00000124875	ENSG00000100985
Uniprot IDs		P80162	P14780
PDB IDs			1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA
Enriched GO Terms of Interacting Partners?		Interleukin-8-mediated Signaling Pathway Leukocyte Migration Dendritic Cell Chemotaxis Dendritic Cell Migration Receptor Internalization Chemokine-mediated Signaling Pathway Chemotaxis Receptor Metabolic Process Cell Migration Leukocyte Chemotaxis Cell Motility Negative Regulation Of Neutrophil Apoptotic Process Cell Chemotaxis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Receptor Binding Response To External Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Receptor-mediated Endocytosis Acute Inflammatory Response To Antigenic Stimulus Immune System Process Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Vascular Permeability Metanephric Tubule Morphogenesis Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Cell Death Regulation Of Cell Motility Endocytosis Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Negative Regulation Of Cation Channel Activity Macrophage Differentiation Regulation Of Cellular Component Movement Positive Regulation Of Neutrophil Chemotaxis Response To Cytokine Neutrophil Activation Positive Regulation Of Granulocyte Chemotaxis Regulation Of Neutrophil Chemotaxis Metanephric Epithelium Development Regulation Of Neutrophil Migration	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Blood Vessel Development Vasculature Development Catabolic Process Regulation Of Body Fluid Levels Response To External Stimulus Chemotaxis Cell Migration Positive Regulation Of Chemotaxis Cell Motility Positive Regulation Of Behavior Immune System Process Regulation Of Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Blood Coagulation Negative Regulation Of Peptidase Activity Inflammatory Response Hemostasis Defense Response Cardiovascular System Development Positive Regulation Of Leukocyte Migration Regulation Of Behavior Platelet Activation Response To Organic Substance Positive Regulation Of Cell Migration Response To Cytokine Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Protein Processing Regulation Of Leukocyte Migration Immune Response Leukocyte Migration Regulation Of Endopeptidase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Hydrolase Activity
Tagcloud ?		act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl2 cxcl5 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Difference) ?		act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl2 cxcl5 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Intersection) ?