CXCL6 and CXCR2

Number of citations of the paper that reports this interaction (PMID 9692902)
19

Data Source:
HPRD (in vivo)

		CXCL6	CXCR2
Gene Name		chemokine (C-X-C motif) ligand 6	chemokine (C-X-C motif) receptor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Mast Cell Granule
	Molecular Function	Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding	Signal Transducer Activity Interleukin-8 Receptor Activity Protein Binding C-X-C Chemokine Receptor Activity Interleukin-8 Binding
	Biological Process	Neutrophil Mediated Immunity Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Lipopolysaccharide Regulation Of Cell Proliferation Defense Response To Bacterium Cell Chemotaxis Chemokine-mediated Signaling Pathway	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)
Protein-Protein Interactions		3 interactors: CXCR1 CXCR2 MMP9	21 interactors: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13
Entrez ID		6372	3579
HPRD ID		00735	00907
Ensembl ID		ENSG00000124875	ENSG00000180871
Uniprot IDs		P80162	P25025 Q53PC4
PDB IDs
Enriched GO Terms of Interacting Partners?		Interleukin-8-mediated Signaling Pathway Leukocyte Migration Dendritic Cell Chemotaxis Dendritic Cell Migration Receptor Internalization Chemokine-mediated Signaling Pathway Chemotaxis Receptor Metabolic Process Cell Migration Leukocyte Chemotaxis Cell Motility Negative Regulation Of Neutrophil Apoptotic Process Cell Chemotaxis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Receptor Binding Response To External Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Receptor-mediated Endocytosis Acute Inflammatory Response To Antigenic Stimulus Immune System Process Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Vascular Permeability Metanephric Tubule Morphogenesis Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Cell Death Regulation Of Cell Motility Endocytosis Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Negative Regulation Of Cation Channel Activity Macrophage Differentiation Regulation Of Cellular Component Movement Positive Regulation Of Neutrophil Chemotaxis Response To Cytokine Neutrophil Activation Positive Regulation Of Granulocyte Chemotaxis Regulation Of Neutrophil Chemotaxis Metanephric Epithelium Development Regulation Of Neutrophil Migration	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Behavior Inflammatory Response Cytokine-mediated Signaling Pathway Signaling Cell Communication Response To Lipopolysaccharide Receptor Metabolic Process Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Platelet Activation Positive Regulation Of Locomotion Signal Transduction Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Chemotaxis Cellular Response To Stimulus Receptor Internalization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Cytokine Response To External Stimulus Response To Bacterium G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Migration Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility Response To Stress Regulation Of Locomotion Cell Activation Blood Coagulation Cellular Response To Organic Substance Regulation Of Cellular Component Movement Hemostasis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Other Organism Response To Stimulus Regulation Of Cell Proliferation Response To Biotic Stimulus
Tagcloud ?		act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl2 cxcl5 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Difference) ?		act1 alpha blot ccl20 changed cultured cxcl1 cxcl2 cxcl5 declined ht il intestinal knockdown line obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	ab attenuating chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Intersection) ?		chemokine chemokines neutrophil