CCL25 and ACKR4

Number of citations of the paper that reports this interaction (PMID 10706668)
23

Data Source:
HPRD (in vitro)

		CCL25	ACKR4
Gene Name		chemokine (C-C motif) ligand 25	atypical chemokine receptor 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome
	Molecular Function	Hormone Activity Chemokine Activity CCR10 Chemokine Receptor Binding Chemokine Receptor Binding	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding Chemokine Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Chemotaxis Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Leukocyte Migration Cell Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling	Receptor-mediated Endocytosis Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ACKR2 ACKR4 CCR10 CCR9	11 interactors: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13
Entrez ID		6370	51554
HPRD ID		03976	07298
Ensembl ID		ENSG00000131142	ENSG00000129048
Uniprot IDs		O15444	Q9NPB9
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Neutrophil Activation G-protein Coupled Receptor Signaling Pathway Locomotion Immune Response Receptor-mediated Endocytosis Response To External Stimulus Cellular Response To Organic Substance Immune System Process Endocytosis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Cytosolic Calcium Ion Homeostasis Defense Response Vesicle-mediated Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Inflammatory Response Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Signal Transduction Leukocyte Activation Cellular Chemical Homeostasis Signaling Ion Homeostasis Cell Communication Cell Activation Cellular Homeostasis Cellular Response To Stimulus Chemical Homeostasis Cellular Defense Response Response To Stress Response To Stimulus Homeostatic Process Transport	Cell Chemotaxis Leukocyte Chemotaxis Leukocyte Migration Inflammatory Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Regulation Of Leukocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Cell Migration Cell Motility Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Homeostasis Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Locomotion Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response Positive Regulation Of Chemotaxis Chemical Homeostasis Positive Regulation Of Behavior Movement Of Cell Or Subcellular Component Regulation Of Chemotaxis Regulation Of Cell Migration Positive Regulation Of Cell Migration Granulocyte Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Response To External Stimulus Regulation Of Cellular Component Movement Regulation Of Behavior Homeostatic Process Immune System Process Response To Stress Regulation Of Granulocyte Chemotaxis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Cell-cell Adhesion
Tagcloud ?		17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1
Tagcloud (Difference) ?		17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1
Tagcloud (Intersection) ?