CCL25 and CCR9

Number of citations of the paper that reports this interaction (PubMedID 10229797)
0

Data Source:
HPRD (in vitro, in vivo)

		CCL25	CCR9
Description		C-C motif chemokine ligand 25	C-C motif chemokine receptor 9
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Chemokine Activity CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Immune System Process Chemotaxis Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Eosinophil Chemotaxis Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Leukocyte Tethering Or Rolling	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Vercirnon
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399)	Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		11 interacting genes: ACKR2 ACKR4 CCL17 CCL5 CCR10 CCR9 CXCL11 CXCL12 CXCL17 PF4 PF4V1	19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE
Entrez ID		6370	10803
HPRD ID		03976	09200
Ensembl ID		ENSG00000131142	ENSG00000173585
Uniprot IDs		O15444	B2R734 P51686
PDB IDs			5LWE
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Chemotaxis Locomotion Chemokine-mediated Signaling Pathway Cell Migration Chemokine Activity Cell Motility Cytokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Immune Response Leukocyte Chemotaxis Immune System Process Antimicrobial Humoral Response Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cytokine Activity Leukocyte Migration Mononuclear Cell Migration G Protein-coupled Receptor Signaling Pathway Humoral Immune Response CXCR Chemokine Receptor Binding Positive Regulation Of Monocyte Chemotaxis Defense Response Inflammatory Response Extracellular Space Killing Of Cells Of Another Organism Regulation Of Monocyte Chemotaxis Myeloid Leukocyte Migration External Side Of Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling CXCR3 Chemokine Receptor Binding Defense Response To Symbiont Defense Response To Other Organism Cell Killing Cell Surface Receptor Signaling Pathway Granulocyte Chemotaxis Chemokine Receptor Binding Granulocyte Migration Signal Transduction Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Transport Response To Other Organism T Cell Chemotaxis Macrophage Chemotaxis Positive Regulation Of Macrophage Chemotaxis G Protein-coupled Receptor Activity Macrophage Migration	Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity
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