BID and CAPN2

Number of citations of the paper that reports this interaction (PMID 12000759)
20

Data Source:
BioGRID (enzymatic study)

		BID	CAPN2
Gene Name		BH3 interacting domain death agonist	calpain 2, (m/II) large subunit
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Mitochondrial Membrane Extracellular Vesicular Exosome	Chromatin Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Dendrite Cortical Actin Cytoskeleton Pseudopodium Membrane Raft Extracellular Vesicular Exosome Perinuclear Endoplasmic Reticulum
	Molecular Function	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cysteine-type Peptidase Activity Protein Heterodimerization Activity
	Biological Process	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Response To Estradiol Positive Regulation Of Protein Oligomerization Positive Regulation Of Protein Homooligomerization Glial Cell Apoptotic Process Regulation Of Cell Proliferation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Protein Homooligomerization Neuron Apoptotic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Protein Autoprocessing Regulation Of Cytoskeleton Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Amino Acid Stimulus
Pathways		Activation of BAD and translocation to mitochondria Activation, translocation and oligomerization of BAX Activation, myristolyation of BID and translocation to mitochondria Programmed Cell Death Activation of BH3-only proteins Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 C14orf1 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL RPA1 SETDB1 TLE1 TUBB2B YWHAB ZHX1	17 interactors: ADRBK1 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 F2RL1 GAS2 KNG1 MAPK1 MAPT NFKBIA NMT1 PTPN1 PTPRN TNS1
Entrez ID		637	824
HPRD ID		03590	00254
Ensembl ID		ENSG00000015475	ENSG00000162909
Uniprot IDs		A8ASI8 B2ZP79 B3KT21 P55957	B4DN77 P17655 Q59EF6
PDB IDs		1ZY3 2BID 2KBW 2M5B 4BD2	1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Death Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Regulation Of Mitochondrial Membrane Potential Protein Processing Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Anoikis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Neuron Apoptotic Process Regulation Of Anoikis Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Response To Stress Neuron Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Cell Death Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cell Communication Response To Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Neuron Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Activation Of Cysteine-type Endopeptidase Activity Regulation Of Membrane Permeability	Regulation Of Cellular Localization Regulation Of Intracellular Transport Positive Regulation Of Transport Peptidyl-threonine Phosphorylation Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Innate Immune Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Peptidyl-serine Phosphorylation Defense Response Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Localization Response To Estrogen Neurotrophin TRK Receptor Signaling Pathway Response To Steroid Hormone Immune Response Neurotrophin Signaling Pathway Response To Lipid Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Intracellular Transport Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Regulation Of Cellular Protein Metabolic Process Response To Stress Establishment Of Localization In Cell Pons Development Response To Hormone Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Mitochondrion Organization Protein Metabolic Process Renal System Process G-protein Coupled Acetylcholine Receptor Signaling Pathway
Tagcloud ?		3n burns catheter caustic cd ceb ceftazidime contents corticosteroids cp created decreasing dexamethasone ensues esophageal esophagograms grouped histologic hydroxide hydroxyproline im indwelling infused massive pentoxifylline scatritial stricture tid wistar	1h basilar camk2a camk2b capn1 cisplatin cochlea deacetylases ganglion hair hdacs immunocytochemistry label neurofilament neurotransmitter newborn organotypic ototoxicity panther phalloidin rab3b rhodamine sgns snap25 spiral tnfrsf1a trichostatin tsa vglut1
Tagcloud (Difference) ?		3n burns catheter caustic cd ceb ceftazidime contents corticosteroids cp created decreasing dexamethasone ensues esophageal esophagograms grouped histologic hydroxide hydroxyproline im indwelling infused massive pentoxifylline scatritial stricture tid wistar	1h basilar camk2a camk2b capn1 cisplatin cochlea deacetylases ganglion hair hdacs immunocytochemistry label neurofilament neurotransmitter newborn organotypic ototoxicity panther phalloidin rab3b rhodamine sgns snap25 spiral tnfrsf1a trichostatin tsa vglut1
Tagcloud (Intersection) ?