BID and CASP2

Number of citations of the paper that reports this interaction (PubMedID 11832478)
0

Data Source:
HPRD (in vitro, in vivo)

		BID	CASP2
Description		BH3 interacting domain death agonist	caspase 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane	Nucleus Nucleolus Cytoplasm Cytosol Endopeptidase Complex
	Molecular Function	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Stress Intracellular Signal Transduction Regulation Of T Cell Proliferation Signal Transduction In Response To DNA Damage Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Epithelial Cell Proliferation Neuron Apoptotic Process Protein-containing Complex Assembly Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Supramolecular Fiber Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Intracellular Signal Transduction Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Luteolysis Neural Retina Development Proteolysis Apoptotic Process DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing DNA Damage Response, Signal Transduction By P53 Class Mediator Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Protein Maturation Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria	NOD1/2 Signaling Pathway NADE modulates death signalling TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Adult body size ( 32376654) Diisocyanate-induced asthma ( 25918132) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		36 interacting genes: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DDIT4L ERG28 FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL SETDB1 TLE1 TUBB2B YWHAB ZHX1	32 interacting genes: ADCYAP1 BAG4 BID CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MAPT MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 PRKAB2 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I
Entrez ID		637	835
HPRD ID		03590	02800
Ensembl ID		ENSG00000015475	ENSG00000106144
Uniprot IDs		A8ASI8 B2ZP79 B3KT21 P55957	A0A087WYM1 A0A0S2Z3H1 P42575
PDB IDs		1ZY3 2BID 2KBW 2M5B 2M5I 4BD2 4QVE 4ZEQ 4ZIG 4ZII 5AJJ 5C3F 7M5A 7M5B 7P33 7QTW 8SM5	1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM 6GKF 6GKG 6S9K 6SAD 6Y8B 6Y8D
Enriched GO Terms of Interacting Partners?		Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Release Of Cytochrome C From Mitochondria Apoptotic Process Cell Death Programmed Cell Death Channel Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Execution Phase Of Apoptosis Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Protein Kinase CK2 Complex Mitochondrial Outer Membrane Cysteine-type Peptidase Activity Regulation Of Apoptotic Process Protein Maturation Regulation Of Programmed Cell Death Identical Protein Binding Leukocyte Apoptotic Process DNA Damage Response Regulation Of Neuron Apoptotic Process Mitochondrial Fusion Negative Regulation Of Anoikis Regulation Of Autophagy Signal Transduction Programmed Cell Death Involved In Cell Development Response To Cytokine Response To Peptide Negative Regulation Of Programmed Cell Death Regulation Of Anoikis Cysteine-type Endopeptidase Activity Peptidase Activity B Cell Homeostasis Cytosol Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Pyroptotic Inflammatory Response Mitochondrion Organization Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Response To Stress B Cell Apoptotic Process Pyroptotic Inflammatory Response	Death Receptor Binding Cell Death Programmed Cell Death Apoptotic Process Cytosol Cytoplasm Regulation Of Apoptotic Process Execution Phase Of Apoptosis Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death Effector Domain Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Apoptotic Signaling Pathway Ripoptosome CD95 Death-inducing Signaling Complex Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death-inducing Signaling Complex Signal Transduction In Response To DNA Damage Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Multicellular Organismal Process Ubiquitin Protein Ligase Binding Pyroptotic Inflammatory Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Nucleus Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Proteolysis Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Enzyme Binding Intracellular Signal Transduction DNA Damage Response Response To Stress Endopeptidase Complex Regulation Of Protein-containing Complex Assembly Positive Regulation Of Signal Transduction Positive Regulation Of Protein Polymerization Cellular Response To Staurosporine Regulation Of Metabolic Process
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